{
  "abstract": "Objectives\n\nTo compare the early stability trajectories of two tissue-level implant macro-designs after immediate placement, using monthly resonance frequency analysis (ISQ) over 6 months.Materials and methods\n\nSingle-center randomized clinical trial in adults requiring immediate implant placement in posterior sites. ISQ was recorded at implant placement and monthly for 6 months. A linear mixed-effects model (subject-level random intercept; fixed effects for group, visit, their interaction, and baseline ISQ) was fitted, with the group × visit interaction as the primary inferential term. The 6-month endpoint was assessed by baseline-adjusted ANCOVA, with equivalence tested against a ±3 ISQ margin (2 one-sided tests).Results\n\nThirty implants were placed in 30 patients (aggressive self-tapping, n = 15; conservative uniform-thread, n = 15). ISQ increased significantly over time in both groups (p < 0.001). The group × visit interaction was significant (χ² = 43.25, df = 5, p < 0.001); baseline-adjusted differences favored the aggressive design at t1 (+3.84 ISQ, 95% CI 1.64 to 6.03; p = 0.004) and t2 (+3.70, 95% CI 1.51 to 5.90; p = 0.005), and were no longer detectable from t3. At 6 months, the baseline-adjusted difference was -0.73 ISQ (95% CI -2.91 to 1.46; p = 0.500), and equivalence within ±3 ISQ was supported (TOST p = 0.021). All aggressive-design implants reached ISQ ≥ 70 by 3 months versus 33% in the conservative group (p = 0.001).Conclusions\n\nWithin the limitations of this trial, the more aggressive macro-design showed significantly higher stability during the first 2 months of healing, with significantly different trajectories over time, whereas at 6 months, no between-group difference was demonstrated and equivalence within the pre-specified ±3 ISQ margin was supported. Macro-design therefore influenced the timing of stability acquisition rather than stability at 6 months, supporting its relevance for early loading protocols.Trial registration\n\nClinicalTrials.gov identifier: NCT06711744; Date of registration: 21 November 2024; EC Protocol ID: 6271 (Ethics Committee Lazio 3).",
  "abstract_shown": true,
  "affiliations": [
    "CL Dentistry, Segni, Italy.",
    "Department of Periodontics and Oral Medicine, School of Dentistry, University of Michigan, Ann Arbor, Michigan, USA.",
    "Division of Fixed Prosthodontics and Biomaterials, University Clinics for Dental Medicine, University of Geneva, Geneva, Switzerland.",
    "Department of Oral Pathology, Oral Medicine, and Oral & Maxillofacial Surgery, University of Tripoli School of Dentistry, Tripoli, Libya.",
    "Private practice, Salerno, Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Paolo Carosi",
      "orcid": "0000-0002-2442-1091"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Andrea Laureti",
      "orcid": "0000-0003-0217-7101"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Abdusalam Alrmali",
      "orcid": "0000-0001-7437-6279"
    },
    {
      "affs": [
        4
      ],
      "name": "Alessandro Pinto",
      "orcid": "0009-0006-4632-3085"
    },
    {
      "affs": [
        1
      ],
      "name": "Hom-Lay Wang",
      "orcid": "0000-0003-4238-1799"
    },
    {
      "affs": [
        0
      ],
      "name": "Claudia Lorenzi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f30mdatame52j.bib",
  "cited_by": 0,
  "doi": "10.1002/cre2.70490",
  "fulltext_url": "https://europepmc.org/articles/PMC13696025",
  "id": "f30mdatame52j",
  "issns": [
    "2057-4347"
  ],
  "landing_url": "https://europepmc.org/article/MED/42927630",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RK1-715"
    ],
    [
      "openalex",
      "3504|Dental Implant Techniques and Outcomes"
    ]
  ],
  "openalex": "W7223571598",
  "pdf_url": "https://europepmc.org/articles/PMC13696025?pdf=render",
  "pmcid": "PMC13696025",
  "pmid": "42927630",
  "published": "2026-10-01",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/f30mdatame52j.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42927630",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42927630"
    },
    {
      "first_seen": "2026-10-31T14:22:49Z",
      "native_id": "05bd425220a54f5b84edd2d0c3e4918f",
      "source": "doaj",
      "url": "https://doi.org/10.1002/cre2.70490"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RK1-715",
      "subfield": "general"
    }
  ],
  "title": "Design Matters? Evaluating Implant Macro-Geometry in Immediate Implants: A Randomized Clinical Trial With Six-Month Interim Analysis.",
  "title_text": "Design Matters? Evaluating Implant Macro-Geometry in Immediate Implants: A Randomized Clinical Trial With Six-Month Interim Analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T14:20:47Z",
  "url": "https://research.draconitic.com/paper/f30mdatame52j",
  "venue": "Clinical and experimental dental research",
  "versions": []
}