{
  "abstract": "Hair loss is a global health problem, and current conventional treatments, despite their effectiveness in delaying hair loss and improving hair growth, suffer from significant side effects and limitations in individualized treatment. In recent years, the application of novel nanotechnology in dermatology and regenerative medicine has gained attention. In this context, researchers explored the potential of applying Spruce-Derived Extracellular Vesicles (SDEVs) to hair loss intervention. Through in vitro experiments and in vivo animal models, it was found that Spruce-Derived Extracellular Vesicles (SDEVs) could improve hair follicles by activating the proliferation of Dermal papilla cells (DPCs) to intervene in hair loss. Spruce-Derived Extracellular Vesicles (SDEVs) significantly improved hair weight, thickness, and luster, and reduced the inflammatory response associated with hair loss compared with conventional treatments. These findings provide new ideas for hair regrowth treatments and demonstrate the potential therapeutic value of Spruce-Derived Extracellular Vesicles (SDEVs) in hair loss prevention.",
  "abstract_shown": true,
  "affiliations": [
    "Shanghai Key Laboratory of Molecular Imaging, Shanghai University of Medicine and Health Sciences, Shanghai, China"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kunchi Zhang"
    },
    {
      "name": "Ying Cao"
    },
    {
      "name": "Zitong Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f3eexh62x235t.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0358041",
  "fulltext_url": null,
  "id": "f3eexh62x235t",
  "issns": [
    "1932-6203"
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  "landing_url": "https://doi.org/10.1371/journal.pone.0358041",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2708|Hair Growth and Disorders"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Integumentary system/Hair"
    ],
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      "plos",
      "/Biology and life sciences/Anatomy/Integumentary system/Hair/Hair follicles"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Integumentary system/Skin/Hair follicles"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Cellular structures and organelles/Vesicles"
    ],
    [
      "plos",
      "/Biology and life sciences/Computational biology/Genome analysis/Gene ontologies"
    ],
    [
      "plos",
      "/Biology and life sciences/Genetics/Genomics/Genome analysis/Gene ontologies"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Endocrine physiology/Growth factors"
    ],
    [
      "plos",
      "/Biology and life sciences/Physiology/Physiological processes/Hair growth"
    ],
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      "plos",
      "/Biology and life sciences/Physiology/Physiological processes/Hair growth/Anagen phase"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Integumentary system/Hair"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Integumentary system/Hair/Hair follicles"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Integumentary system/Skin/Hair follicles"
    ],
    [
      "plos",
      "/Medicine and health sciences/Endocrinology/Endocrine physiology/Growth factors"
    ],
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      "plos",
      "/Research and analysis methods/Biological cultures/Cell cultures"
    ]
  ],
  "openalex": "W7225417602",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/f3eexh62x235t.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:24Z",
      "native_id": "10.1371/journal.pone.0358041",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0358041"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
    }
  ],
  "title": "Spruce-derived extracellular vesicles (SDEVs) improve hair loss by activating the proliferation of dermal papilla cells",
  "title_text": "Spruce-derived extracellular vesicles (SDEVs) improve hair loss by activating the proliferation of dermal papilla cells",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:20:48Z",
  "url": "https://research.draconitic.com/paper/f3eexh62x235t",
  "venue": "PLOS One",
  "versions": []
}