{
  "abstract": "The mechanisms regulating glioma cell death are poorly understood. Here, we developed a high-throughput method to study cell death in patient-derived glioblastoma (GBM) and diffuse intrinsic pontine glioma (DIPG) spheroids. Using this method, we systematically profiled how extracellular ligands modulate compound-induced cell death. We find that bone morphogenetic protein 2 (BMP2) and BMP4 potently rewire cell death sensitivity. These ligands suppress killing by standard-of-care DNA alkylating agents and kinase inhibitors by inhibiting cell cycle progression. Simultaneously, BMP2/4 prime spheroids for lipid-dependent necrosis (LiDN), a palmitate-dependent form of non-apoptotic cell death that can be triggered by the clinical drug candidate tegavivint. Activating mutations in the BMP receptor ACVR1, found in ~25% of DIPG tumors, are sufficient to prime cells for LiDN in the absence of BMP ligand. Together, these findings identify a cell death switch that can be activated in glioma cells by BMP signaling.",
  "abstract_shown": true,
  "affiliations": [
    "Stanford University"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "name": "W. C. Lee"
    },
    {
      "name": "J. J. Salinas"
    },
    {
      "name": "A. Gautam"
    },
    {
      "name": "D. Cadet"
    },
    {
      "name": "M. A. Banu"
    },
    {
      "name": "D. A. Nathanson"
    },
    {
      "affs": [
        0
      ],
      "name": "S. J. Dixon"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f40t8te5kzqq9.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.10.750657",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750657v1.full",
  "id": "f40t8te5kzqq9",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750657v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "cancer biology"
    ],
    [
      "openalex",
      "1312|Cell death mechanisms and regulation"
    ]
  ],
  "openalex": "W7212445644",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750657v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-10",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/f40t8te5kzqq9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:54Z",
      "native_id": "10.64898/2026.09.10.750657",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.09.10.750657v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "biorxiv:cancer biology",
      "subfield": "oncology"
    }
  ],
  "title": "High-throughput spheroid profiling reveals BMP-driven rewiring of glioma cell death responses",
  "title_text": "High-throughput spheroid profiling reveals BMP-driven rewiring of glioma cell death responses",
  "type": "preprint",
  "updated_at": "2026-10-30T12:21:54Z",
  "url": "https://research.draconitic.com/paper/f40t8te5kzqq9",
  "venue": "bioRxiv",
  "versions": []
}