{
  "abstract": "This study presents the development and validation of a multi-residue screening method for the determination of 196 analytes in meat and milk using LC-Q-Orbitrap mass spectrometer in accordance with Commission Implementing Regulation (CIR) (EU) 2021/808. Four different multi-residue extraction methods from the literature were compared, and a double extraction combining an acetonitrile/water mixture followed by pure acetonitrile was selected as the most effective approach. The performance of the method showed good specificity for 87% of the target analytes. False negative results remained limited, affecting 6% of analytes in muscle and 8% in milk, and highlighting a few problematic compounds. The detection capability (CCβ) ranged from 5 to 10 µg/kg for 80% of the analytes in both matrices, whereas for the other substances CCβ values were found in the range of 50 to 100 µg/kg. In addition, the method fulfilled the quantification criteria of the CIR (EU) 2021/808 for 106 analytes in muscle and 115 analytes in milk at concentrations ranging from 5 µg/kg to 100 µg/kg. The method was further subjected to external evaluation through participation in different proficiency testing schemes for the determination of multi-class of VMPs. The results showed no false negatives and all obtained z-scores entered within the satisfactory range of ±2, proving that the method is suitable for both qualitative and quantitative screening of veterinary drug residues in animal-derived products and could be envisaged for somehow confirmatory status.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "name": "Dominique Hurtaud-Pessel"
    },
    {
      "name": "Pierrick Couedor"
    },
    {
      "name": "Khaled El Hawari"
    },
    {
      "name": "Eric Verdon"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f4cwmwnhcgf5e.bib",
  "cited_by": 1,
  "doi": "10.1016/j.chroma.2026.467411",
  "fulltext_url": null,
  "id": "f4cwmwnhcgf5e",
  "issns": [
    "0021-9673",
    "1873-3778"
  ],
  "landing_url": "https://anses.hal.science/anses-05801509v1",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "hal",
      "0.chim"
    ],
    [
      "hal",
      "1.chim.anal"
    ],
    [
      "openalex",
      "1106|Pesticide Residue Analysis and Safety"
    ]
  ],
  "openalex": "W7162508665",
  "pdf_url": "https://anses.hal.science/anses-05801509/document",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-25",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/f4cwmwnhcgf5e.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:57Z",
      "native_id": "anses-05801509",
      "source": "hal",
      "url": "https://anses.hal.science/anses-05801509v1"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "hal:1.chim.anal",
      "subfield": "analytical"
    }
  ],
  "title": "High resolution mass spectrometry screening method for routine surveillance of pharmacologically active substance residues in meat and milk",
  "title_text": "High resolution mass spectrometry screening method for routine surveillance of pharmacologically active substance residues in meat and milk",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:57Z",
  "url": "https://research.draconitic.com/paper/f4cwmwnhcgf5e",
  "venue": "Journal of Chromatography A",
  "versions": []
}