{
  "abstract": "Chronic kidney disease–mineral and bone disorder (CKD-MBD) promotes coronary artery calcification (CAC), MicroRNAs may serve as potential biomarkers for its progression. This study aimed to evaluate the circulating miRNA-21-5p, miRNA-486-5p, and miRNA-122-5p as potential diagnostic markers of CAC in CKD-MBD patients and assess their association with CAC score and identify their putative target genes and associated biological pathways using an in-silico approach. This case-control investigation encompassed 150 participants (50 CKD-MBD, 50 CKD, and 50 healthy controls) were analyzed for miRNA expression via qRT-PCR and CAC score via non-contrast cardiac computed tomography (CT) Agatston scoring. miRNA-21-5p expression was significantly elevated in CKD-MBD group and positively correlated with parathyroid hormone (PTH), fibroblast growth factor-23 (FGF-23), and CAC score. Conversely, miR-486-5p was significantly downregulated and showed a negative correlation with CAC score in CKD-MBD group. miRNA-122-5p showed no significant differences or associations across all patients’ groups. In-silico analysis revealed that miR-486-5p potentially targets genes critically involved in renal pathology, and cardiac calcium homeostasis. MiR-21-5p was predicted to target a reno-protective gene, indicating a pathogenic role for miR-21-5p upregulation in CKD. Circulating miRNA-486-5p and miRNA-21-5p were promising non-invasive biomarkers that could be used to improve the diagnosis of coronary calcification in CKD-MBD patients. The in-silico study suggests that they play distinct yet interconnected roles in the molecular mechanisms underlying CKD and CAC.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "name": "Enas Ahmed Osman",
      "orcid": "0000-0002-8217-2265"
    },
    {
      "name": "Noha Hamdy Eltaweel"
    },
    {
      "name": "Medhat Madbouly"
    },
    {
      "name": "Mohamed Hosni Kamel Abdelmaksoud"
    },
    {
      "name": "Mohamed Moharam Mohamed Hussin"
    },
    {
      "name": "Mohammed Ghanem Gaber"
    },
    {
      "name": "Anas Hassan Ibrahim"
    },
    {
      "name": "Ahmed Mohamed Ali Elmaghraby"
    },
    {
      "name": "Farida Mohamed Khanany"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f4mxwnpq1x8rx.bib",
  "cited_by": 0,
  "doi": "10.1038/s41598-026-71224-8",
  "fulltext_url": null,
  "id": "f4mxwnpq1x8rx",
  "issns": [
    "2045-2322"
  ],
  "landing_url": "https://www.nature.com/articles/s41598-026-71224-8",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2727|Parathyroid Disorders and Treatments"
    ]
  ],
  "openalex": "W7219848470",
  "pdf_url": "https://www.nature.com/articles/s41598-026-71224-8.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-04",
  "publisher": "Springer Science and Business Media LLC",
  "ris": "https://research.draconitic.com/paper/f4mxwnpq1x8rx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:22Z",
      "native_id": "10.1038/s41598-026-71224-8",
      "source": "crossref",
      "url": "https://www.nature.com/articles/s41598-026-71224-8"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2727|Parathyroid Disorders and Treatments",
      "subfield": "general"
    }
  ],
  "title": "Circulating miRNA-21-5p, miRNA-486-5p, and miRNA-122-5p as predictors of coronary artery calcification in patients with chronic kidney disease",
  "title_text": "Circulating miRNA-21-5p, miRNA-486-5p, and miRNA-122-5p as predictors of coronary artery calcification in patients with chronic kidney disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:22Z",
  "url": "https://research.draconitic.com/paper/f4mxwnpq1x8rx",
  "venue": "Scientific Reports",
  "versions": []
}