{
  "abstract": "Purpose: To provide an updated and comprehensive assessment of euploid embryo rates in polycystic ovarian syndrome (PCOS) women compared with non-PCOS counterparts undergoing preimplantation genetic testing for aneuploidy (PGT-A), and to evaluate early spontaneous miscarriage (ESM) rates across different PCOS phenotypes following single vitrified euploid blastocyst transfer cycles.\n\nMethods: This retrospective cohort study (2017–2023) included women with PCOS and non-PCOS controls. Two cohorts were analyzed: first PGT-A cycles and first single vitrified euploid blastocyst transfers. ESM and euploidy rates were assessed, and regression analyses were performed to identify factors associated with miscarriage.\n\nResults: In the PCOS group, a total of 1,274 blastocysts were biopsied, of which 580 were euploid, yielding a euploidy rate of 45.53% (580/1,274), which was significantly higher than the 39.86% (1,935/4,854) observed in non-PCOS women (P < 0.001). Additionally, 345 PCOS and 1,650 non-PCOS frozen-thawed embryo transfer cycles involving the first single vitrified euploid blastocyst were included in the analysis. ESM rates were 14.48% (21/145) in the polycystic ovarian morphology (PCOM)+ ovulation disorder (OD) subgroup, 18.75% (6/32) in the PCOM+ Hyperandrogenism (HA) subgroup, and 31.70% (13/41) in the PCOM + OD+HA subgroup. After adjusting for covariates, the PCOM + OD+HA phenotype remained an independent risk factor for ESM (adjusted OR: 2.164; 95% CI: 1.209–6.247; P = 0.036).\n\nConclusion: The high ESM rate observed in PCOS patients may be attributable to their endocrine abnormalities. These findings suggest that non-genetic, environmental factors—rather than genetic factors—warrant greater attention in future strategies aimed at reducing ESM in this population.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12884-026-09718-6.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Reproductive Medicine, Henan Key Laboratory of Reproduction and Genetics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052 China",
    "Henan Institute of Medical & Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450052 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhiqin Bu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaofei Ge"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Sun"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Keyan Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f4rre5sbjh63y.bib",
  "cited_by": 0,
  "doi": "10.1186/s12884-026-09718-6",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13715247/",
  "id": "f4rre5sbjh63y",
  "issns": [
    "1471-2393"
  ],
  "landing_url": "https://doi.org/10.1186/s12884-026-09718-6",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2743|Ovarian function and disorders"
    ]
  ],
  "openalex": "W7172027580",
  "pdf_url": null,
  "pmcid": "PMC13715247",
  "pmid": "42947040",
  "published": "2026-07-31",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/f4rre5sbjh63y.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:22:36Z",
      "native_id": "PMC13715247",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12884-026-09718-6"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2743|Ovarian function and disorders",
      "subfield": "reproductive-child"
    }
  ],
  "title": "Genetic and non-genetic contributions to early spontaneous miscarriage in women with PCOS undergoing PGT-A and single euploid blastocyst transfer: a retrospective cohort study",
  "title_text": "Genetic and non-genetic contributions to early spontaneous miscarriage in women with PCOS undergoing PGT-A and single euploid blastocyst transfer: a retrospective cohort study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:36Z",
  "url": "https://research.draconitic.com/paper/f4rre5sbjh63y",
  "venue": "BMC Pregnancy and Childbirth",
  "versions": []
}