{
  "abstract": "Rosa rugosa root extract (RR-r) has been used in East Asian medicine to treat metabolic disorders, including diabetes and alcohol-induced liver toxicity. Although RR-r has been demonstrated to exhibit anti-inflammatory and antioxidant properties, further research is required to elucidate its protective effects against ultraviolet B (UVB)-induced skin photoaging. In this study, high-performance liquid chromatography was used to identify rutin as the major indicator compound of RR-r. The photoprotective activity of RR-r was evaluated using a mouse model of UVB-induced skin damage. Mice were orally administered RR-r (100 or 200 mg/kg) for 8 weeks during UVB irradiation. RR-r significantly alleviated UVB-induced wrinkle formation, epidermal thickening, and collagen fiber degradation. The assessment of skin morphology and hydration was conducted through the use of histological staining (H&E and Masson's trichrome), wrinkle and moisture analysis, and enzyme-linked immunosorbent assay quantification of hyaluronic acid. Western blotting revealed that RR-r increased pro-collagen type I, tissue inhibitor of metalloproteinases 1, hyaluronan, collagen-1 while reducing the matrix metalloproteinase family, hyaluronidase 1 and hyaluronidase 2. A further mechanistic analysis revealed that RR-r inhibited UVB-induced phosphorylation of mitogen-activated protein kinase pathway components and downstream activator protein-1 factors. Furthermore, RR-r significantly suppressed UVB-induced accumulation of advanced glycation end products (AGEs) and expression of their receptor, RAGE. Collectively, these findings demonstrate that oral RR-r effectively protects against UVB-induced photoaging by regulating wrinkle-related proteins, enhancing skin hydration, and modulating MAPK/AP-1 and AGE-RAGE signaling. Thus, RR-r may represent a promising natural candidate for skin anti-aging interventions.",
  "abstract_shown": true,
  "affiliations": [
    "Food Functionality Research Division Korea Food Research Institute Wanju-gun Jeonbuk-do Republic of Korea.",
    "Division of Food Biotechnology University of Science and Technology Daejeon Republic of Korea."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Min Ji Gu",
      "orcid": "0009-0004-3300-7548"
    },
    {
      "affs": [
        0
      ],
      "name": "Guijae Yoo",
      "orcid": "0000-0003-1939-0187"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sang-Hoon Lee",
      "orcid": "0000-0002-2920-4213"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Ho-Young Park",
      "orcid": "0000-0002-9966-9059"
    },
    {
      "affs": [
        0
      ],
      "name": "Yoonsook Kim",
      "orcid": "0000-0002-9060-7134"
    },
    {
      "affs": [
        0
      ],
      "name": "Donghwan Kim",
      "orcid": "0000-0002-0139-2494"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sang Keun Ha",
      "orcid": "0000-0002-3329-2279"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f4wsekvd10395.bib",
  "cited_by": 0,
  "doi": "10.1002/fsn3.72462",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717222/?tool=EBI",
  "id": "f4wsekvd10395",
  "issns": [
    "2048-7177"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13717222",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2708|Skin Protection and Aging"
    ]
  ],
  "openalex": "W7224636408",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13717222/pdf/?tool=EBI",
  "pmcid": "PMC13717222",
  "pmid": "42959397",
  "published": "2026-10-28",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/f4wsekvd10395.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:37Z",
      "native_id": "PMC:PMC13717222",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13717222"
    },
    {
      "first_seen": "2026-10-31T12:21:46Z",
      "native_id": "MED:42959397",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42959397"
    },
    {
      "first_seen": "2026-11-02T12:21:34Z",
      "native_id": "PMC13717222",
      "source": "pmc",
      "url": "https://doi.org/10.1002/fsn3.72462"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2708|Skin Protection and Aging",
      "subfield": "general"
    }
  ],
  "title": "Rosa rugosa Root Extract as a Functional Food Ingredient, Mitigating UVB‐Induced Skin Aging Through MAPK/AP‐1 and AGE‐RAGE Pathway Modulation",
  "title_text": "Rosa rugosa Root Extract as a Functional Food Ingredient, Mitigating UVB‐Induced Skin Aging Through MAPK/AP‐1 and AGE‐RAGE Pathway Modulation",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:21:34Z",
  "url": "https://research.draconitic.com/paper/f4wsekvd10395",
  "venue": "Food science & nutrition",
  "versions": []
}