{
  "abstract": "Background\n\nAbdominal wall hernias remain a significant clinical challenge, necessitating advanced repair materials that balance mechanical strength with biocompatibility. The drawbacks of polypropylene (PP) mesh limit its application scenarios.Objective\n\nThe present study aimed to develop a degradable anti-adhesion composite PP scaffold (PLLA-(HA-ATE)-PP) and evaluate its potential efficacy in hernia repair.Materials and methods\n\nWe used coaxial electrospinning to fabricate scaffolds on PP substrates, combining poly-L-lactic acid (PLLA), sodium hyaluronate (HA), and adipose tissue extract (ATE). The scaffold was characterized via SEM, mechanical testing, water contact angle measurement, and weight gain/loss analysis. In vitro cytocompatibility was assessed using L929 fibroblasts through CCK-8 and Live/Dead assays. In vivo performance was evaluated in a rat abdominal wall defect model (2.0cm×2.0cm) by analyzing adhesion formation, peritonealization, scaffold shrinkage, inflammatory response, and TGF-β1/MMP2 expression.Results\n\nThe PLLA-(HA-ATE) scaffold was successfully fabricated, with an average diameter of 0.956 ± 0.414 µm. PLLA-(HA-ATE)-PP scaffold exhibited good mechanical properties (Young's modulus 44.92 MPa) that far exceeded the stress intensity of native abdominal wall. The scaffold's hydrophilicity was enhanced, with water absorption peaking within 4 hours. Cytocompatibility assessed via L929 fibroblasts showed promoted proliferation and adhesion. In a rat abdominal wall defect model, the scaffold effectively repaired defects, reduced adhesion area (e.g., significant anti-adhesion vs. PP group), and accelerated peritonealization, while alleviating foreign body reaction. Additionally, it down-regulated TGF-β1 expression, inhibiting fibrosis.Conclusion\n\nThe PLLA-(HA-ATE)-PP scaffold combines biodegradability with anti-adhesion properties, improving abdominal wall repair and positioning it as a promising clinical candidate. The combination of in vitro and in vivo evaluations demonstrates the scaffold's potential for clinical translation.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastrointestinal Surgery, Fifth Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, China.",
    "Department of General Surgery, Zhongda Hospital, Southeast University, Nanjing, Jiangsu, 210009, China.",
    "Department of General Surgery, Zhongda Hospital Lishui Branch Southeast University, Nanjing,Jiangsu, 211200, China."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Zhigang Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Qiaochun Kou"
    },
    {
      "affs": [
        0
      ],
      "name": "Song Gao"
    },
    {
      "affs": [
        0
      ],
      "name": "Guangtao Zheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Xinxin Tian"
    },
    {
      "affs": [
        0
      ],
      "name": "Muladili Tulahong"
    },
    {
      "affs": [
        2
      ],
      "name": "Nengqi Cao"
    },
    {
      "affs": [
        0
      ],
      "name": "Lei Wang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f4x18fnqweh35.bib",
  "cited_by": 0,
  "doi": "10.30498/ijb.2025.557432.4281",
  "fulltext_url": "https://europepmc.org/articles/PMC13695771",
  "id": "f4x18fnqweh35",
  "issns": [
    "1728-3043",
    "2322-2921"
  ],
  "landing_url": "https://europepmc.org/article/MED/42928726",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2746|Hernia repair and management"
    ]
  ],
  "openalex": "W7223675139",
  "pdf_url": "https://europepmc.org/articles/PMC13695771?pdf=render",
  "pmcid": "PMC13695771",
  "pmid": "42928726",
  "published": "2026-10-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/f4x18fnqweh35.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:21:18Z",
      "native_id": "MED:42928726",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42928726"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2746|Hernia repair and management",
      "subfield": "surgery"
    }
  ],
  "title": "Biodegradable electrospun PLLA/HA-ATE composite polypropylene scaffold for hernia repair applications.",
  "title_text": "Biodegradable electrospun PLLA/HA-ATE composite polypropylene scaffold for hernia repair applications.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:18Z",
  "url": "https://research.draconitic.com/paper/f4x18fnqweh35",
  "venue": "Iranian journal of biotechnology",
  "versions": []
}