{
  "abstract": "Hypertrophic cardiomyopathy (HCM) is a genetic heart disease characterized by left ventricular hypertrophy. Mutations in genes for sarcomere proteins, e.g., in cardiac myosin-binding protein C (cMyBPC), may cause symptoms like heart failure and sudden cardiac death. In HCM, the heart utilizes high amounts of glucose. Increased glucose metabolism creates intermediates for hyaluronan (HA) synthesis, resulting in HA accumulation within the extracellular space, which could contribute to cardiomyocyte hypertrophy. We aimed to describe the connection between HA and cardiomyocyte hypertrophy using cMyBPC+/- mice treated with two different β-blockers – either metoprolol or propranolol – for 11 months. The results showed that HA metabolism is altered in HCM, and that HA is significantly more abundant in hearts of cMyBPC+/- mice compared to wild-type mice. Areas of high HA abundance were spread around the tissue in a ‘patchy’ manner. This focally increased HA concentration correlated with increased cardiomyocyte size in the same areas of the heart. Gene expression of HA synthase 2 was elevated in cMyBPC+/- mice. Treatment with propranolol maintained HA synthase 2 at wild-type level, while significantly increasing HA synthase 3 expression. However, treatment with metoprolol or propranolol did not prevent HA accumulation nor decreased cardiomyocyte hypertrophy. These novel findings visualise a spatial connection between high HA abundance and cardiomyocyte hypertrophy in the hearts of cMyBPC+/- mice.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden",
    "Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden",
    "Umeå Centre for Molecular Medicine, Umeå University, Umeå, Sweden",
    "Department of Chemistry, Umeå University, Umeå, Sweden",
    "Department of Clinical Microbiology, Umeå University, Umeå, Sweden"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anna Strnadová"
    },
    {
      "affs": [
        1
      ],
      "name": "Madelene Ericsson"
    },
    {
      "affs": [
        2
      ],
      "name": "Rakel Nyrén"
    },
    {
      "affs": [
        3
      ],
      "name": "Ilona Dudka"
    },
    {
      "affs": [
        4
      ],
      "name": "Stellan Mörner"
    },
    {
      "name": "Urban Hellman"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f4yektkw4dbnt.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0342635",
  "fulltext_url": null,
  "id": "f4yektkw4dbnt",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0342635",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2705|Cardiomyopathy and Myosin Studies"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Biological tissue/Muscle tissue/Muscle cells/Cardiomyocytes"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Cardiovascular anatomy/Heart"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Metabolism/Carbohydrate metabolism/Glucose metabolism"
    ],
    [
      "plos",
      "/Biology and life sciences/Cell biology/Cellular types/Animal cells/Muscle cells/Cardiomyocytes"
    ],
    [
      "plos",
      "/Biology and life sciences/Genetics/Gene expression"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Biological tissue/Muscle tissue/Muscle cells/Cardiomyocytes"
    ],
    [
      "plos",
      "/Medicine and health sciences/Anatomy/Cardiovascular anatomy/Heart"
    ],
    [
      "plos",
      "/Medicine and health sciences/Cardiology/Cardiac hypertrophy"
    ],
    [
      "plos",
      "/Medicine and health sciences/Pharmaceutics/Drug therapy/Receptor antagonist therapy/Beta-adrenergic antagonist therapy"
    ],
    [
      "plos",
      "/Physical sciences/Chemistry/Chemical compounds/Organic compounds/Carbohydrates/Monosaccharides/Glucose"
    ],
    [
      "plos",
      "/Physical sciences/Chemistry/Organic chemistry/Organic compounds/Carbohydrates/Monosaccharides/Glucose"
    ],
    [
      "plos",
      "/Research and analysis methods/Animal studies/Experimental organism systems/Animal models/Mouse models"
    ],
    [
      "plos",
      "/Research and analysis methods/Animal studies/Experimental organism systems/Model organisms/Mouse models"
    ],
    [
      "plos",
      "/Research and analysis methods/Model organisms/Mouse models"
    ]
  ],
  "openalex": "W7212036670",
  "pdf_url": "https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0342635&type=printable",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-09",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/f4yektkw4dbnt.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
      "native_id": "10.1371/journal.pone.0342635",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0342635"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
    }
  ],
  "title": "Cardiomyocyte hypertrophy co-localizes with accumulation of hyaluronan in cMyBPC+/- mice hearts",
  "title_text": "Cardiomyocyte hypertrophy co-localizes with accumulation of hyaluronan in cMyBPC+/- mice hearts",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:56Z",
  "url": "https://research.draconitic.com/paper/f4yektkw4dbnt",
  "venue": "PLOS One",
  "versions": []
}