{
  "abstract": "Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by persistent joint inflammation and progressive disability. Although current therapies have improved clinical outcomes, safer and more effective therapeutic approaches remain needed. Silicon (Si)-based agents have antioxidant and anti-inflammatory properties and have shown beneficial effects in several inflammatory disease models. Methods: We evaluated the effects of oral administration of a Si-based agent in a type II collagen-induced arthritis mouse model. Arthritis severity was assessed using an arthritis index, hindlimb oedema, and the hindlimb extension reflex test. Serum type II collagen-specific autoantibody levels were also measured. Vestibular function was evaluated using the vestibulo-ocular reflex (VOR), and inner-ear structural changes were assessed by magnetic resonance imaging and histological analysis. Results: The Si-based agent reduced arthritis-related outcomes, including the arthritis index, hindlimb oedema, and joint movement restriction, and reduced serum type II collagen-specific autoantibody levels. In contrast, no significant differences between the Si-based agent and control groups were detected in VOR-related outcomes, endolymphatic space measurements, or inner-ear histological findings. Conclusions: These findings suggest that the Si-based agent may have beneficial effects on arthritis-related manifestations. However, its effects on the vestibular function-related outcomes examined in this study were not evident. Further studies are needed to clarify the relationship between RA and vestibular dysfunction and to determine the potential therapeutic effects of Si-based agent on these complications.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Otorhinolaryngology-Head and Neck Surgery, Graduate School of Medicine, The University of Osaka, Suita, Japan",
    "Department of Neuroscience and Cell Biology, Graduate School of Medicine, The University of Osaka, Suita, Japan",
    "Addiction Research Unit, Osaka Psychiatric Research Center, Osaka Psychiatric Medical Center, Osaka, Japan",
    "SANKEN, The University of Osaka, Suita, Japan",
    "Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan",
    "Institute for Biomedical Sciences, Iwate Medical University, Morioka, Japan"
  ],
  "article_type": "Research Article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Shotaro Harada"
    },
    {
      "affs": [
        1
      ],
      "name": "Yoshihisa Koyama"
    },
    {
      "affs": [
        2
      ],
      "name": "Yuki Kobayashi"
    },
    {
      "affs": [
        3
      ],
      "name": "Takao Imai"
    },
    {
      "affs": [
        4
      ],
      "name": "Yoshichika Yoshioka"
    },
    {
      "affs": [
        5
      ],
      "name": "Hikaru Kobayashi"
    },
    {
      "name": "Hidenori Inohara"
    },
    {
      "name": "Shoichi Shimada"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f4yxhc6eqrbsx.bib",
  "cited_by": 0,
  "doi": "10.1371/journal.pone.0361954",
  "fulltext_url": null,
  "id": "f4yxhc6eqrbsx",
  "issns": [
    "1932-6203"
  ],
  "landing_url": "https://doi.org/10.1371/journal.pone.0361954",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2745|Rheumatoid Arthritis Research and Therapies"
    ],
    [
      "plos",
      "/Biology and life sciences/Anatomy/Head/Ears/Inner ear"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/Collagens"
    ],
    [
      "plos",
      "/Biology and life sciences/Biochemistry/Proteins/Immune system proteins/Antibodies/Autoantibodies"
    ],
    [
      "plos",
      "/Biology and life sciences/Immunology/Clinical immunology/Autoimmune diseases/Rheumatoid arthritis"
    ],
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      "/Biology and life sciences/Immunology/Immune system proteins/Antibodies/Autoantibodies"
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    [
      "plos",
      "/Biology and life sciences/Physiology/Immune physiology/Antibodies/Autoantibodies"
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    [
      "plos",
      "/Medicine and health sciences/Anatomy/Head/Ears/Inner ear"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Clinical immunology/Autoimmune diseases/Rheumatoid arthritis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Clinical medicine/Signs and symptoms/Edema"
    ],
    [
      "plos",
      "/Medicine and health sciences/Diagnostic medicine/Diagnostic radiology/Magnetic resonance imaging"
    ],
    [
      "plos",
      "/Medicine and health sciences/Immunology/Clinical immunology/Autoimmune diseases/Rheumatoid arthritis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Immunology/Immune system proteins/Antibodies/Autoantibodies"
    ],
    [
      "plos",
      "/Medicine and health sciences/Radiology and imaging/Diagnostic radiology/Magnetic resonance imaging"
    ],
    [
      "plos",
      "/Medicine and health sciences/Rheumatology/Arthritis"
    ],
    [
      "plos",
      "/Medicine and health sciences/Rheumatology/Arthritis/Rheumatoid arthritis"
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      "/Research and analysis methods/Animal studies/Experimental organism systems/Animal models/Mouse models"
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    [
      "plos",
      "/Research and analysis methods/Animal studies/Experimental organism systems/Model organisms/Mouse models"
    ],
    [
      "plos",
      "/Research and analysis methods/Imaging techniques/Diagnostic radiology/Magnetic resonance imaging"
    ],
    [
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  "openalex": "W7225398512",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-06",
  "publisher": "Public Library of Science",
  "ris": "https://research.draconitic.com/paper/f4yxhc6eqrbsx.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:20:24Z",
      "native_id": "10.1371/journal.pone.0361954",
      "source": "plos",
      "url": "https://doi.org/10.1371/journal.pone.0361954"
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  "subjects": [
    {
      "field": "biology",
      "origin": "plos:immunology",
      "subfield": "immunology"
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    {
      "field": "medicine",
      "origin": "plos:diagnostic radiology",
      "subfield": "imaging"
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    {
      "field": "medicine",
      "origin": "plos:anatomy",
      "subfield": "physiology"
    }
  ],
  "title": "Evaluation of the efficacy of Si-based agent in Rheumatoid Arthritis with complicating vestibular impairment",
  "title_text": "Evaluation of the efficacy of Si-based agent in Rheumatoid Arthritis with complicating vestibular impairment",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:20:48Z",
  "url": "https://research.draconitic.com/paper/f4yxhc6eqrbsx",
  "venue": "PLOS One",
  "versions": []
}