{
  "abstract": "IntroductionParkinsons Disease (PD) motor features typically begin unilaterally, but it remains unclear whether dominant versus non-dominant side motor symptoms differentially affect lateralized aspects of fine motor control.\n\nMethodsWe recruited 16 right-handed participants with mild, asymmetric PD (8 primarily left-side affected, 8 primarily right-side affected) and 10 age-matched controls to complete a bimanual tablet task in which one hand draws a stylus to targets (leveraging trajectory control mechanisms) while the other hand simultaneously stabilizes a stylus over a stationary target (leveraging stabilizing control mechanisms). The styli are connected via a resistance band to mimic internal forces that arise during asymmetric, bimanual activities of daily living.\n\nResultsBoth PD groups demonstrated preserved trajectory control in their dominant hand relative to controls (p > .072), but significantly impaired stabilizing control in their non-dominant hand (p < .022), with the largest deficits observed in the left-side PD group. Trajectory control performance significantly correlated with an overall measure of motor severity (r(14) = .69; p = .004), while stabilizing control did not (p = .56).\n\nDiscussionThese findings suggest that left- and right-side motor symptoms in early PD produce distinct patterns of functional impairment (rather than simple contralateral analogs) that may be related to underlying lateralized motor control mechanisms. This work highlights a potential gap in standard clinical motor assessments, which may not adequately capture non-dominant side stabilizing deficits in early PD.",
  "abstract_shown": true,
  "affiliations": [
    "Virginia Commonwealth University"
  ],
  "article_type": "PUBLISHAHEADOFPRINT",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "B. Dexheimer"
    },
    {
      "name": "C. Selb"
    },
    {
      "name": "J. Manning"
    },
    {
      "name": "N. Yaghoubi"
    },
    {
      "name": "A. Porreca"
    },
    {
      "name": "M. J. Barrett"
    },
    {
      "name": "P. E. Pidcoe"
    },
    {
      "name": "D. Krusienski"
    },
    {
      "name": "B. D. Berman"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f533124dgdh5r.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.09.09.26362567",
  "fulltext_url": "https://www.medrxiv.org/content/10.64898/2026.09.09.26362567v1.full",
  "id": "f533124dgdh5r",
  "issns": [],
  "landing_url": "https://www.medrxiv.org/content/10.64898/2026.09.09.26362567v1",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "medrxiv",
      "neurology"
    ],
    [
      "openalex",
      "2805|Motor Control and Adaptation"
    ]
  ],
  "openalex": "W7212377112",
  "pdf_url": "https://www.medrxiv.org/content/10.64898/2026.09.09.26362567v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/f533124dgdh5r.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:25Z",
      "native_id": "10.64898/2026.09.09.26362567",
      "source": "medrxiv",
      "url": "https://www.medrxiv.org/content/10.64898/2026.09.09.26362567v1"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "medrxiv:neurology",
      "subfield": "neurology"
    }
  ],
  "title": "Lateralized motor control mechanisms underlie lateralized motor deficits in early Parkinson's Disease",
  "title_text": "Lateralized motor control mechanisms underlie lateralized motor deficits in early Parkinson's Disease",
  "type": "preprint",
  "updated_at": "2026-10-30T12:18:25Z",
  "url": "https://research.draconitic.com/paper/f533124dgdh5r",
  "venue": "medRxiv",
  "versions": []
}