{
  "abstract": "Objective: This study aimed to evaluate the impact of three lifestyle interventions on perceived physical fatigability.\n\nMethods: Concurrent with a dietary weight loss program (caloric deficit ~400 kcal/day, weekly dietitian support), older adults with obesity (N = 183) were randomized to three groups: aerobic exercise (150–200 min/week of moderate‐intensity treadmill walking; n = 60), daylong movement (improving daily activity distribution, progressively increase steps/day; n = 63), or combination (aerobic and daylong movement interventions; n = 60). Perceived physical fatigability (Pittsburgh Fatigability Scale [PFS] Physical score, range 0–50, and Rating of Perceived Exertion [RPE] after a 5‐min 0% grade treadmill walk, range 6–20; higher = greater fatigability) was measured at baseline, 6 months (post‐intensive intervention), and 18 months (end of maintenance period).\n\nResults: Participants (69.6 ± 4.3 years, 77% female, 74% White, 35.6 ± 3.8 kg/m2 BMI) had a PFS Physical score 20.6 ± 7.6 and RPE Fatigability 9.6 ± 1.9 at baseline. Clinically relevant improvements were observed in PFS score from baseline to 6 months (−4.4 points, p = 0.002) and were largely maintained at 18 months (−3.0 points, p = 0.03) after adjustment for baseline age, sex, education, intervention group, and time × intervention group (p = 0.83). RPE Fatigability did not improve (p > 0.05).\n\nConclusions: Multiple physical activity strategies in conjunction with weight loss improved perceived physical fatigability over time among older adults with obesity.\n\nTrial Registration: ClinicalTrials.gov identifier: NCT02923674",
  "abstract_shown": true,
  "affiliations": [
    "Department of Epidemiology University of Pittsburgh School of Public Health Pittsburgh Pennsylvania USA",
    "Department of Health and Exercise Sciences Wake Forest University Winston‐Salem North Carolina USA",
    "Department of Psychiatry University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA",
    "Department of Biostatistics and Health Data Science University of Pittsburgh School of Public Health Pittsburgh Pennsylvania USA",
    "Department of Health and Human Development University of Pittsburgh School of Education Pittsburgh Pennsylvania USA",
    "Department of Internal Medicine, Section on Gerontology and Geriatric Medicine Wake Forest University School of Medicine Winston‐Salem North Carolina USA"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Reagan E. Garcia"
    },
    {
      "affs": [
        1
      ],
      "name": "Jason Fanning"
    },
    {
      "affs": [
        2,
        3
      ],
      "name": "Chaeryon Kang",
      "orcid": "0000-0001-9442-8515"
    },
    {
      "affs": [
        0
      ],
      "name": "Bonny Rockette‐Wagner",
      "orcid": "0000-0002-4096-917X"
    },
    {
      "affs": [
        4
      ],
      "name": "Christopher E. Kline",
      "orcid": "0000-0003-1025-9430"
    },
    {
      "affs": [
        5
      ],
      "name": "Barbara J. Nicklas"
    },
    {
      "affs": [
        0
      ],
      "name": "Nancy W. Glynn",
      "orcid": "0000-0003-2265-0162"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f5as0ct0dykwg.bib",
  "cited_by": 0,
  "doi": "10.1002/oby.70298",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13716182/",
  "id": "f5as0ct0dykwg",
  "issns": [
    "1930-7381",
    "1930-739X"
  ],
  "landing_url": "https://doi.org/10.1002/oby.70298",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Clinical Trials and Investigations"
    ],
    [
      "heading",
      "ORIGINAL ARTICLE"
    ],
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2737|Physical Activity and Health"
    ]
  ],
  "openalex": "W7212050085",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/oby.70298",
  "pmcid": "PMC13716182",
  "pmid": "42716533",
  "published": "2026-09-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/f5as0ct0dykwg.ris",
  "sources": [
    {
      "first_seen": "2026-11-01T12:23:14Z",
      "native_id": "PMC13716182",
      "source": "pmc",
      "url": "https://doi.org/10.1002/oby.70298"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Physical Activity and Health",
      "subfield": "physiology"
    }
  ],
  "title": "Weight Loss and Physical Activity Reduces Perceived Physical Fatigability Among Older Adults With Obesity",
  "title_text": "Weight Loss and Physical Activity Reduces Perceived Physical Fatigability Among Older Adults With Obesity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:14Z",
  "url": "https://research.draconitic.com/paper/f5as0ct0dykwg",
  "venue": "Obesity (Silver Spring, Md.)",
  "versions": []
}