{
  "abstract": "Repeated lipopolysaccharide (LPS) exposure compromises broiler growth and hepatic homeostasis. This study investigated the effects of dietary dimethylglycine sodium salt (DMG-Na) on hepatic responses to repeated LPS challenge and breast-muscle quality. A total of 320 one-day-old male Arbor Acres broilers were assigned to a 2 × 2 factorial design with 0 or 0.4 g DMG-Na/kg basal diet and saline or LPS (10 cages of 8 birds per treatment). Lipopolysaccharide (1 mg/kg body weight) was administered intraperitoneally on d 17, 19, and 21. DMG-Na × LPS interactions were detected for postchallenge average daily gain (P = 0.038), feed conversion ratio (P = 0.031), hepatic histopathological score (P = 0.013), and swollen mitochondrial profiles (P = 0.002). Relative to LPS alone, DMG-Na supplementation reduced histopathological score, mitochondrial swelling, and fraction-associated protein carbonyl content and was accompanied by lower hepatic SIRT1 protein abundance and phosphorylated NF-κB p65 abundance in LPSD birds (P < 0.05). Factorial transcriptomics and metabolomics identified 138 interaction-associated genes and 126 metabolite features, respectively, involving inflammatory and redox-related processes. Hepatic mtDNA abundance increased, whereas ATP and respiratory-chain complex activities remained unchanged. Breast-muscle drip loss showed an interaction (P = 0.041), but supplementation did not significantly alter drip loss within LPS-challenged birds. The treatment-only regression model outperformed the hepatic-variable random forest in predicting drip loss. Dietary DMG-Na improved postchallenge feed efficiency and attenuated hepatic inflammatory, redox, and structural alterations in LPS-challenged broilers.",
  "abstract_shown": true,
  "affiliations": [
    "College of Biology and Environmental Engineering, Zhejiang Shuren University, Hangzhou, 310023, China",
    "School of Biological and Chemical Engineering, Zhejiang University of Science and Technology, Hangzhou, 310023, China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Luyi Jiang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yaqi Rao"
    },
    {
      "affs": [
        1
      ],
      "name": "Kaiwen Bai"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f5x6y4sj79ttv.bib",
  "cited_by": 0,
  "doi": "10.1016/j.psj.2026.107994",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718808/?tool=EBI",
  "id": "f5x6y4sj79ttv",
  "issns": [
    "0032-5791",
    "1525-3171"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13718808",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "IMMUNOLOGY, HEALTH AND DISEASE"
    ],
    [
      "openalex",
      "1103|Animal Nutrition and Physiology"
    ]
  ],
  "openalex": "W7222999261",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13718808/pdf/?tool=EBI",
  "pmcid": "PMC13718808",
  "pmid": "42906441",
  "published": "2026-10-20",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/f5x6y4sj79ttv.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:38Z",
      "native_id": "PMC:PMC13718808",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13718808"
    },
    {
      "first_seen": "2026-11-02T12:22:46Z",
      "native_id": "PMC13718808",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.psj.2026.107994"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1103|Animal Nutrition and Physiology",
      "subfield": "zoology-behaviour"
    }
  ],
  "title": "Dietary dimethylglycine sodium salt attenuates lipopolysaccharide-associated hepatic alterations and modulates redox responses in broiler chickens",
  "title_text": "Dietary dimethylglycine sodium salt attenuates lipopolysaccharide-associated hepatic alterations and modulates redox responses in broiler chickens",
  "type": "peer-reviewed",
  "updated_at": "2026-11-02T12:22:46Z",
  "url": "https://research.draconitic.com/paper/f5x6y4sj79ttv",
  "venue": "Poultry science",
  "versions": []
}