{
  "abstract": "To examine the association between central adiposity, assessed by waist-to-height ratio (WHtR), and tear film stability in adults with obesity. This cross-sectional observational study included 269 adults with BMI ≥ 28 kg/m2. WHtR and noninvasive tear breakup time (NIBUT) were the primary exposure and outcome. Models adjusted for age, sex, education, systemic diseases, myopia, display exposure, smoking, alcohol consumption, and sleep problems. Secondary outcomes were Ocular Surface Disease Index (OSDI) and dry eye disease (DED) status; other adiposity indices were examined in separate models. Each 1-SD higher WHtR was associated with shorter NIBUT (adjusted β -0.341 s; 95% CI -0.612--0.071; p = 0.014). The highest versus lowest WHtR tertile differed by -0.961 s (95% CI -1.696--0.227). BMI had a numerically larger coefficient (-0.591 s; 95% CI -0.842--0.339). DED was present in 208 participants (77.3%). The WHtR-DED association was nominally significant (OR 1.630; 95% CI 1.072-2.477; p = 0.022) but did not survive false discovery rate correction (q = 0.061). Higher WHtR was associated with modestly shorter NIBUT among adults with obesity, while BMI showed a numerically larger association. These findings support considering overall and abdominal adiposity in the clinical assessment of ocular surface function.",
  "abstract_shown": true,
  "affiliations": [
    "Beijing Institute of Ophthalmology Beijing Tongren Eye Center Beijing Tongren Hospital Beijing Ophthalmology & Visual Sciences Key Laboratory Capital Medical University Beijing 100730 China ccmu.edu.cn.",
    "School of Basic Medical Sciences Capital Medical University Beijing 100069 China ccmu.edu.cn.",
    "Physical Examination Center Hebei General Hospital Shijiazhuang 050051 China hebmu.edu.cn."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ao Li",
      "orcid": "0000-0002-2278-8148"
    },
    {
      "affs": [
        0
      ],
      "name": "Yifei Wu",
      "orcid": "0009-0004-6560-8727"
    },
    {
      "affs": [
        1
      ],
      "name": "Rongteng Lin"
    },
    {
      "affs": [
        1
      ],
      "name": "Yubo Wu",
      "orcid": "0009-0000-7933-7164"
    },
    {
      "affs": [
        2
      ],
      "name": "Qian Nie"
    },
    {
      "affs": [
        0
      ],
      "name": "Lei Tian",
      "orcid": "0000-0002-7216-5352"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying Jie",
      "orcid": "0000-0003-2649-8241"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f69qts63z26bt.bib",
  "cited_by": 0,
  "doi": "10.1155/joph/7742500",
  "fulltext_url": "https://europepmc.org/articles/PMC13740966",
  "id": "f69qts63z26bt",
  "issns": [
    "2090-004X",
    "2090-0058"
  ],
  "landing_url": "https://europepmc.org/article/MED/42997162",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2731|Ocular Surface and Contact Lens"
    ]
  ],
  "openalex": "W7225409152",
  "pdf_url": "https://europepmc.org/articles/PMC13740966?pdf=render",
  "pmcid": "PMC13740966",
  "pmid": "42997162",
  "published": "2026-11-06",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/f69qts63z26bt.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T15:20:34Z",
      "native_id": "MED:42997162",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42997162"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2731|Ocular Surface and Contact Lens",
      "subfield": "general"
    }
  ],
  "title": "Central Adiposity and Tear Film Instability in Adults With Obesity.",
  "title_text": "Central Adiposity and Tear Film Instability in Adults With Obesity.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T15:20:34Z",
  "url": "https://research.draconitic.com/paper/f69qts63z26bt",
  "venue": "Journal of ophthalmology",
  "versions": []
}