{
  "abstract": "Purpose: This study aimed to evaluate the sex- and age-specific survival impacts of body composition (BC) parameters in patients with surgically treated gastroesophageal cancer.\n\nMethods: A total of 1382 patients were retrospectively analyzed. The skeletal muscle index (SMI), skeletal muscle radiodensity (SMD), and visceral/subcutaneous adipose tissue index (VATI/SATI) were determined. The survival impacts of the BC parameters were investigated according to age (≥ 75 or < 75 years) and sex. Multivariate Cox hazard models were used to identify independent predictors of a poor overall survival (OS) and cancer-specific survival (CSS).\n\nResults: The median age was 67 years, and 1028 (74.4%) patients were male. A low SMI (P < 0.001), a low SATI (P = 0.048), and a low SMD (P = 0.01) were independent predictors of poor OS in younger patients; however, only a low SMI (P < 0.001) had an independent impact on OS in the older group. In male patients, all four BC measures significantly demarcated OS curves (all P < 0.01), and a low SMI had an independent impact on CSS (P = 0.03). In contrast, in female patients, only SMI and SATI reliably discriminated OS curves (both P < 0.001), and a low SATI was an independent predictor of a poor CSS (P = 0.008).\n\nConclusions: The prognostic implications of the BC parameters may vary by age and sex in patients with gastroesophageal cancer.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1007/s00595-026-03458-y.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Gastrointestinal Surgery, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113- 8655 Japan",
    "Department of Radiology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan",
    "Department of Urology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Kotaro Sugawara"
    },
    {
      "affs": [
        0
      ],
      "name": "Shinichiro Shiomi"
    },
    {
      "affs": [
        1
      ],
      "name": "Wataru Gonoi"
    },
    {
      "affs": [
        2
      ],
      "name": "Satoru Taguchi"
    },
    {
      "affs": [
        1
      ],
      "name": "Shouhei Hanaoka"
    },
    {
      "affs": [
        0
      ],
      "name": "Koichi Yagi"
    },
    {
      "affs": [
        1
      ],
      "name": "Osamu Abe"
    },
    {
      "affs": [
        2
      ],
      "name": "Haruki Kume"
    },
    {
      "affs": [
        0
      ],
      "name": "Yoshifumi Baba"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f6bn1pwvg9bs4.bib",
  "cited_by": 0,
  "doi": "10.1007/s00595-026-03458-y",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13722632/",
  "id": "f6bn1pwvg9bs4",
  "issns": [
    "0941-1291",
    "1436-2813"
  ],
  "landing_url": "https://doi.org/10.1007/s00595-026-03458-y",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2737|Nutrition and Health in Aging"
    ]
  ],
  "openalex": "W7201859508",
  "pdf_url": "https://link.springer.com/content/pdf/10.1007/s00595-026-03458-y.pdf",
  "pmcid": "PMC13722632",
  "pmid": "42566025",
  "published": "2026-08-07",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/f6bn1pwvg9bs4.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:21:25Z",
      "native_id": "PMC13722632",
      "source": "pmc",
      "url": "https://doi.org/10.1007/s00595-026-03458-y"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2737|Nutrition and Health in Aging",
      "subfield": "physiology"
    }
  ],
  "title": "Sex- and the age-specific survival impacts of multiple body composition parameters in patients with gastroesophageal cancers",
  "title_text": "Sex- and the age-specific survival impacts of multiple body composition parameters in patients with gastroesophageal cancers",
  "type": "peer-reviewed",
  "updated_at": "2026-11-04T12:21:25Z",
  "url": "https://research.draconitic.com/paper/f6bn1pwvg9bs4",
  "venue": "Surgery Today",
  "versions": []
}