{
  "abstract": "Subclass cell types are strongly conserved across mammalian brains, making the systemic absence of a caudal ganglionic eminence (CGE) Pax6 interneuron subclass in mouse transcriptional atlases unexpected. Through cross-species transcriptomic analysis, we identify a Pax6 subclass homolog in mouse and uncover primate-specific divergence in the Sncg subclass. Analyses of electrophysiological and spatial datasets reveal limited subclass-specific structure in either modality, emphasizing the superior resolving power of transcriptomics for subclass distinctions. Our results highlight the pitfalls of relying on small sets of marker genes in cell-type annotation and provide evolution-aware annotations and marker sets to support robust cross-mammal interneuron comparisons.",
  "abstract_shown": true,
  "affiliations": [
    "Physiology Department and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jonathan M Werner"
    },
    {
      "affs": [
        0
      ],
      "name": "Hamsini Suresh"
    },
    {
      "affs": [
        0
      ],
      "name": "Leon French"
    },
    {
      "affs": [
        0
      ],
      "name": "Jesse Gillis",
      "orcid": "0000-0002-0936-9774"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f6cchdtcd8se6.bib",
  "cited_by": 0,
  "doi": "10.1016/j.isci.2026.117632",
  "fulltext_url": "https://europepmc.org/articles/PMC13639153",
  "id": "f6cchdtcd8se6",
  "issns": [
    "2589-0042"
  ],
  "landing_url": "https://europepmc.org/article/MED/42840470",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Single-cell and spatial transcriptomics"
    ]
  ],
  "openalex": "W7214500191",
  "pdf_url": "https://europepmc.org/articles/PMC13639153?pdf=render",
  "pmcid": "PMC13639153",
  "pmid": "42840470",
  "published": "2026-09-26",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/f6cchdtcd8se6.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:10Z",
      "native_id": "MED:42840470",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42840470"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Single-cell and spatial transcriptomics",
      "subfield": "molecular-biology"
    }
  ],
  "title": "The misplaced mouse Pax6 interneuron subclass: A cross-species transcriptomic reassignment.",
  "title_text": "The misplaced mouse Pax6 interneuron subclass: A cross-species transcriptomic reassignment.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:18:10Z",
  "url": "https://research.draconitic.com/paper/f6cchdtcd8se6",
  "venue": "IScience",
  "versions": []
}