{
  "abstract": "Objective: Behçet’s disease (BD) is a systemic vasculitis characterized by thrombo-inflammation. This cross-sectional study compared inflammatory indices obtained from complete blood counts (CBC), focusing particularly on red blood cell distribution width (RDW), with conventional acute-phase reactants (CRP, ESR). It examined phenotype-specific hematological patterns across clinical manifestations and the cross-sectional relationships of hematological parameters and vascular involvement with treatments. Subjects and Methods: A total of 100 BD patients (ISG criteria) and 42 age- and sex-comparable healthy controls were studied. RDW, MPV, PHR, and CBC-derived indices (NLR, PLR, MLR, SII, SIRI, AISI) were calculated. Disease activity (BDCAF), clinical manifestations (DVT, composite vascular complications, genital ulcer history, arthralgia, pathergy), and treatment regimens were recorded. Between-group comparisons used the Mann–Whitney U test; separation from controls was assessed by ROC analysis with Youden-derived cut-offs. The Benjamini–Hochberg procedure controlled the false discovery rate (FDR) across subgroup comparisons. Results: CRP (p = 0.299) and ESR (p = 0.184) did not differ between groups, whereas RDW (median 15.05% [IQR 13.57–16.32] vs. 13.45% [12.90–13.70], p < 0.001) and MPV (8.85 fL [8.38–10.00] vs. 10.05 fL [9.30–10.60], p < 0.001) did. RDW showed the highest observed AUC for separation from controls (AUC 0.77; cut-off > 13.95), followed by MPV (AUC 0.72); CRP (AUC 0.551) and NLR (AUC 0.49) were uninformative. PHR was nominally lower in DVT (median 17.08 [IQR 15.66–18.97] vs. 20.08 [16.54–25.64], p = 0.043) and composite vascular complications (17.16 [15.23–19.28] vs. 20.22 [16.66–26.26], p = 0.024), accompanied by higher hemoglobin (p = 0.013) and hematocrit (p = 0.006). RDW was lower in patients with a history of genital ulcers (13.65% [IQR 13.07–14.35] vs. 15.70% [14.17–16.45], p < 0.001). After Benjamini–Hochberg correction, the BD–control differences and the genital ulcer–RDW association remained significant, whereas marginal subgroup associations (DVT–PHR, pathergy–SIRI/AISI; p = 0.02–0.05) did not. Colchicine use was nominally associated with a lower DVT frequency (8.1% vs. 28.6%; OR 0.23, 95% CI 0.05–1.24), an unstable, exploratory finding based on only 14 non-users and substantially confounded by indication. Conclusions: In BD, CBC-derived indices, particularly RDW and MPV, separated BD patients from healthy controls even when conventional acute-phase reactants (CRP and ESR) remained normal, although this reflects separation from health rather than diagnostic accuracy for BD. RDW was lower in patients with a history of genital ulcers, while an exploratory PHR signal in deep vein thrombosis was inconclusive. These readily accessible indices may serve as complementary markers in BD, pending validation in disease-controlled prospective studies.",
  "abstract_shown": true,
  "affiliations": [
    "Rheumatology Clinic, Bolu Abant Izzet Baysal University Izzet Baysal Training and Research Hospital, Bolu 14000, Türkiye",
    "Rheumatology Clinic, Diyarbakır Gazi Yasargil Training and Research Hospital, Diyarbakır 21000, Türkiye",
    "Department of Physical Medicine and Rehabilitation, Sakarya Training and Research Hospital, Sakarya 54000, Türkiye",
    "Department of Physical Medicine and Rehabilitation, Division of Algology, Sakarya University Faculty of Medicine, Sakarya 54000, Türkiye",
    "Division of Rheumatology, Division of Rheumatology Sakarya University Faculty of Medicine, Sakarya 54000, Türkiye"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Gamze Dilek",
      "orcid": "0000-0002-0029-9933"
    },
    {
      "affs": [
        1
      ],
      "name": "Mehtap Kalcik Unan"
    },
    {
      "affs": [
        2
      ],
      "name": "Emre Uzun",
      "orcid": "0000-0002-4394-1906"
    },
    {
      "affs": [
        3
      ],
      "name": "Kemal Nas"
    },
    {
      "affs": [
        4
      ],
      "name": "Ayhan Kamanli"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f6j56rkh35t8w.bib",
  "cited_by": 0,
  "doi": "10.3390/metabo16110804",
  "fulltext_url": null,
  "id": "f6j56rkh35t8w",
  "issns": [
    "2218-1989"
  ],
  "landing_url": "https://www.mdpi.com/2218-1989/16/11/804",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2731|Ocular Diseases and Behçet’s Syndrome"
    ]
  ],
  "openalex": "W7223174270",
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-22",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/f6j56rkh35t8w.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:00Z",
      "native_id": "10.3390/metabo16110804",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-1989/16/11/804"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:2218-1989",
      "subfield": "proteomics-metabolomics"
    }
  ],
  "title": "Red Cell Distribution Width and Hematological Patterns in Behçet’s Disease",
  "title_text": "Red Cell Distribution Width and Hematological Patterns in Behçet’s Disease",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:00Z",
  "url": "https://research.draconitic.com/paper/f6j56rkh35t8w",
  "venue": "Metabolites",
  "versions": []
}