{
  "abstract": "Acute lung injury (ALI) leads to severe pulmonary inflammation and alveolar-capillary barrier disruption, with therapy limited by poor solubility and bioavailability of anti-inflammatory agents. To address the limited aqueous solubility, insufficient lesion accumulation, and poor bioavailability of andrographolide (ANDRO) in ALI therapy, an inflammation-responsive nanoprodrug platform (NanoPro5000@ANDRO) was developed via subcomponent self-assembly using dynamic boronic ester and imine linkages, thereby enabling both chemical conjugation and physical encapsulation of ANDRO at a total drug-loading content of 30.24% with an average hydrodynamic diameter of 206.4 nm. This platform exhibited excellent biocompatibility, including a hemolysis rate of <5% and protein adsorption of <10%, and achieved 82.1% cumulative ANDRO release at 48 h under acidic and oxidative conditions, facilitating inflammation-associated lesion-specific drug delivery. Furthermore, the nanosystem exhibited enhanced pulmonary accumulation in inflamed lung tissues, suppressed pro-inflammatory cytokines, including tumor necrosis factor-α and interleukin (IL)-6, upregulated anti-inflammatory mediators, including IL-4 and IL-10, reduced oxidative stress, and promoted M2 macrophage polarization. These combined effects alleviated cytokine storm, restored inflammatory microenvironment homeostasis, and attenuated lipopolysaccharide-induced ALI-associated tissue damage with confirmed biosafety. Overall, this study presents a dual dynamic covalent bond-based nanoprodrug strategy featuring dual ANDRO loading and pH/reactive oxygen species-responsive release behavior, providing a promising therapeutic approach for cytokine-associated inflammatory pulmonary diseases.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "name": "Yin Zhou"
    },
    {
      "name": "Jiayi Wang"
    },
    {
      "name": "Yi Chen"
    },
    {
      "name": "Zijie Li"
    },
    {
      "name": "Gustavo Puras"
    },
    {
      "name": "José Luis Pedraz"
    },
    {
      "name": "Zhongwei Gu"
    },
    {
      "name": "Yiyan He"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f6jxjz22stpax.bib",
  "cited_by": 0,
  "doi": "10.1016/j.ajps.2026.101200",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S1818087626000863",
  "id": "f6jxjz22stpax",
  "issns": [
    "1818-0876",
    "2221-285X"
  ],
  "landing_url": "https://doi.org/10.1016/j.ajps.2026.101200",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "lcc",
      "RM1-950"
    ],
    [
      "openalex",
      "2502|Nanoparticle-Based Drug Delivery"
    ]
  ],
  "openalex": "W7212369863",
  "pdf_url": "https://www.sciencedirect.com/science/article/pii/S1818087626000863/pdf",
  "pmcid": "PMC13715310",
  "pmid": "42953303",
  "published": "2026-09-12",
  "publisher": "KeAi Communications Co., Ltd.",
  "ris": "https://research.draconitic.com/paper/f6jxjz22stpax.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:29Z",
      "native_id": "1c08233bb48b452c94b38d107cec231f",
      "source": "doaj",
      "url": "https://doi.org/10.1016/j.ajps.2026.101200"
    },
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953303",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953303"
    },
    {
      "first_seen": "2026-11-01T12:22:39Z",
      "native_id": "PMC13715310",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.ajps.2026.101200"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2502|Nanoparticle-Based Drug Delivery",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Inflammation-triggered andrographolide nanoprodrug platform for lung-targeted delivery and immune homeostasis recovery: A therapeutic strategy against cytokine storm",
  "title_text": "Inflammation-triggered andrographolide nanoprodrug platform for lung-targeted delivery and immune homeostasis recovery: A therapeutic strategy against cytokine storm",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:39Z",
  "url": "https://research.draconitic.com/paper/f6jxjz22stpax",
  "venue": "Asian Journal of Pharmaceutical Sciences",
  "versions": []
}