{
  "abstract": "Background: Guillain-Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy associated with substantial morbidity, but contemporary data on post-discharge readmission remain limited. We characterized 90-day readmission timing, causes, associated factors, and procedure coding after GBS.\n\nMethods: We analyzed an unweighted cohort of adults with a principal diagnosis of GBS in the 2020 Nationwide Readmissions Database. The primary outcome was all-cause readmission within 90 days after discharge. Readmission causes were classified using principal readmission diagnoses mapped to Clinical Classifications Software Refined categories, and procedure coding was descriptively assessed using ICD-10 procedure codes and procedure-day variables. Logistic regression models were used to identify factors associated with readmission.\n\nResults: Among 2,587 adults eligible for 90-day follow-up, 364 (14.1%) were readmitted. Readmissions clustered early, with 170 (46.7%) occurring within 15 days and 241 (66.2%) within 30 days. Separately, GBS was the principal diagnosis in 170 of 364 readmissions (46.7%), representing the largest grouped cause followed by septicemia (9.6%) and cardiovascular or thromboembolic conditions (6.9%). In adjusted analyses, discharge disposition was the most consistent marker of readmission risk: compared with routine home discharge, facility discharge was associated with higher odds of 90-day readmission (odds ratio 1.70, 95% confidence interval 1.27–2.28). Procedure-code timing suggested that diagnostic evaluation and immunotherapy were administered early, whereas plasma exchange, tracheostomy, gastrostomy, and rehabilitation-related procedures were performed at later stages.\n\nConclusions: Readmission after GBS is frequent, early, and clinically heterogeneous, supporting its interpretation as a marker of residual neurological disability, systemic complications, and care-transition vulnerability rather than recurrent GBS alone.\n\nSupplementary Information: The online version contains supplementary material available at https://doi.org/10.1186/s12883-026-05499-9.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany",
    "Department of Orthopedics and Trauma Surgery, St. Josef Hospital Bochum, Bochum, Germany",
    "Department of Neurology, University Hospital Münster, Münster, Germany",
    "Department of Neurology, Hannover Medical School, Hannover, Germany",
    "College of Medicine, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK",
    "Swedish Neuroscience Institute, Swedish Medical Center, Seattle, WA USA",
    "Digital Engineering Faculty, Hasso Plattner Institute, University of Potsdam, Potsdam, Germany"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Jan Voth"
    },
    {
      "affs": [
        1
      ],
      "name": "Julius Gerstmeyer"
    },
    {
      "affs": [
        2
      ],
      "name": "Sven G. Meuth"
    },
    {
      "affs": [
        2
      ],
      "name": "Gerd Meyer zu Hörste"
    },
    {
      "affs": [
        2
      ],
      "name": "Alice Grizzel Willison"
    },
    {
      "affs": [
        3
      ],
      "name": "Franz Felix Konen"
    },
    {
      "affs": [
        4
      ],
      "name": "Hugh John Willison"
    },
    {
      "affs": [
        3
      ],
      "name": "Thomas Skripuletz"
    },
    {
      "affs": [
        0
      ],
      "name": "Michael Gliem"
    },
    {
      "affs": [
        2
      ],
      "name": "Marc Pawlitzki"
    },
    {
      "affs": [
        5
      ],
      "name": "Jens Chapman"
    },
    {
      "affs": [
        0,
        6
      ],
      "name": "Lars Masanneck",
      "orcid": "0000-0003-2496-1415"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f6k2pa6drybnx.bib",
  "cited_by": 0,
  "doi": "10.1186/s12883-026-05499-9",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13733053/",
  "id": "f6k2pa6drybnx",
  "issns": [
    "1471-2377"
  ],
  "landing_url": "https://doi.org/10.1186/s12883-026-05499-9",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research"
    ],
    [
      "openalex",
      "2728|Peripheral Neuropathies and Disorders"
    ]
  ],
  "openalex": "W7223108774",
  "pdf_url": null,
  "pmcid": "PMC13733053",
  "pmid": "42983686",
  "published": "2026-10-22",
  "publisher": "BMC",
  "ris": "https://research.draconitic.com/paper/f6k2pa6drybnx.ris",
  "sources": [
    {
      "first_seen": "2026-11-08T12:22:55Z",
      "native_id": "PMC13733053",
      "source": "pmc",
      "url": "https://doi.org/10.1186/s12883-026-05499-9"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Peripheral Neuropathies and Disorders",
      "subfield": "neurology"
    }
  ],
  "title": "Real-world hospitalization and readmission trajectory after Guillain-Barré syndrome in the United States",
  "title_text": "Real-world hospitalization and readmission trajectory after Guillain-Barré syndrome in the United States",
  "type": "peer-reviewed",
  "updated_at": "2026-11-08T12:22:55Z",
  "url": "https://research.draconitic.com/paper/f6k2pa6drybnx",
  "venue": "BMC Neurology",
  "versions": []
}