{
  "abstract": "Multinuclear lanthanide‐organic polyhedra offer attractive molecular scaffolds for biomedical imaging, while their predictable construction remains challenging because the high coordination numbers and kinetic lability of lanthanide ions often compromise both topological fidelity and aqueous stability. Here, we develop a coordination‐node‐encoding strategy in which a deprotonation‐stabilized terpyridine‐bis(tetrazolate) chelate preorganizes the local lanthanide coordination environment and thereby programs subsequent self‐assembly. Systematic variation of ligand connectivity affords a family of anionic lanthanide‐organic polyhedra spanning triangular, macrocyclic, tetrahedral, and trigonal‐prismatic topologies. Structural analyses and control experiments demonstrate that cooperative pentadentate chelation coupled with deprotonation imposes the directional coordination constraints required for topology‐selective assembly, while the anionic tetrazolate‐rich surfaces enhance the hydrophilic character and aqueous compatibility of the assemblies. The GdIII truncated‐tetrahedral polyhedron exhibits a per‐GdIII longitudinal relaxivity of 27.9 mM−1·s−1 at 9.4 T and 298 K, approximately sevenfold higher than that of Gd‐DTPA measured under identical conditions, corresponding to a molecular relaxivity of 167.1 mM−1·s−1. The EuIII analogues display characteristic red luminescence with high photoluminescence quantum yields (up to 54%) and enable low‐toxicity cellular imaging. Mixed Eu/Gd polyhedra further integrate EuIII luminescence and GdIII magnetic‐resonance contrast within a single molecular architecture, enabling luminescence and MR imaging. This work establishes coordination‐node encoding as a modular design principle for predictable lanthanide polyhedron formation and provides a versatile platform for developing multifunctional lanthanide‐based imaging systems with enhanced aqueous compatibility.",
  "abstract_shown": true,
  "affiliations": [
    "State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou China",
    "Department of Chemistry Jinan University Guangzhou China",
    "School of Pharmacy Gannan Medical University Ganzhou China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Xin‐Ran Gan"
    },
    {
      "affs": [
        1
      ],
      "name": "Guanning Huang"
    },
    {
      "affs": [
        2
      ],
      "name": "Shao‐Jun Hu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ze‐Hong Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Fan Yin"
    },
    {
      "affs": [
        0
      ],
      "name": "Li‐Peng Zhou"
    },
    {
      "affs": [
        0
      ],
      "name": "Xi Meng"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiao‐Qing Guo"
    },
    {
      "affs": [
        1
      ],
      "name": "Tianfeng Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Qing‐Fu Sun"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f74w6vje4fw97.bib",
  "cited_by": 0,
  "doi": "10.1002/agt2.70469",
  "fulltext_url": "https://doi.org/10.1002/agt2.70469",
  "id": "f74w6vje4fw97",
  "issns": [
    "2692-4560"
  ],
  "landing_url": "https://doi.org/10.1002/agt2.70469",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "QD1-999"
    ],
    [
      "lcc",
      "QH301-705.5"
    ],
    [
      "openalex",
      "2505|Lanthanide and Transition Metal Complexes"
    ]
  ],
  "openalex": "W7224126136",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/agt2.70469",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-31",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/f74w6vje4fw97.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T14:22:18Z",
      "native_id": "0fddfd5e338b4e19a8fbc473e3da99e1",
      "source": "doaj",
      "url": "https://doi.org/10.1002/agt2.70469"
    }
  ],
  "subjects": [
    {
      "field": "chemistry",
      "origin": "openalex:2505|Lanthanide and Transition Metal Complexes",
      "subfield": "materials-polymers"
    }
  ],
  "title": "Node‐Encoded Control of Lanthanide Self‐Assembly Enables Predictable and Water‐Stable Polyhedra for Bioimaging",
  "title_text": "Node‐Encoded Control of Lanthanide Self‐Assembly Enables Predictable and Water‐Stable Polyhedra for Bioimaging",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T14:22:18Z",
  "url": "https://research.draconitic.com/paper/f74w6vje4fw97",
  "venue": "Aggregate",
  "versions": []
}