{
  "abstract": "Background: Cardiac amyloidosis is increasingly recognized in older patients with severe aortic stenosis, yet advanced pressure-overload remodeling can produce overlapping imaging features that confound noninvasive diagnosis.\n\nCase Summary: A 70-year-old woman presented with progressive exertional dyspnea and markedly elevated cardiac biomarkers. Transthoracic echocardiography revealed extremely severe calcific aortic stenosis, increased left ventricular wall thickness, and severely reduced global longitudinal strain. Cardiac magnetic resonance imaging demonstrated elevated native T1 and extracellular volume with late gadolinium enhancement, and cardiac amyloid radionuclide imaging showed Perugini grade 1 uptake. Despite clinical suspicion of cardiac amyloidosis, noninvasive findings remained inconclusive. The patient underwent surgical aortic valve replacement with intraoperative myocardial biopsy, which demonstrated cardiomyocyte hypertrophy and interstitial fibrosis without amyloid deposition, consistent with advanced pressure-overload remodeling rather than infiltrative disease.\n\nDiscussion: Extremely severe aortic stenosis can mimic cardiac amyloidosis across multiple imaging modalities. Histologic confirmation remains essential when noninvasive findings are discordant or inconclusive.\n\nTake-Home Messages: Severe aortic stenosis may closely mimic cardiac amyloidosis on multimodality imaging. Histological confirmation can be decisive in resolving diagnostic uncertainty.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Internal Medicine, Pusan National University Hospital, Busan, Republic of Korea",
    "Department of Nuclear Medicine, Pusan National University Hospital, Busan, Republic of Korea",
    "School of Medicine, Pusan National University, Busan, Republic of Korea",
    "Department of Radiology, Pusan National University Hospital, Pusan National University School of Medicine and Medical Research Institute, Busan, South Korea",
    "Division of Cardiology, Department of Internal Medicine, Pusan National University Hospital, Pusan National University School of Medicine, Busan, Republic of Korea",
    "Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea"
  ],
  "article_type": "case report",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Yu Young Kim"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Kyoungjune Pak"
    },
    {
      "affs": [
        3
      ],
      "name": "Ji Won Lee"
    },
    {
      "affs": [
        4,
        5
      ],
      "name": "Jung Hyun Choi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f79x0y8c27a6m.bib",
  "cited_by": 0,
  "doi": "10.1016/j.jaccas.2026.110353",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13699046/",
  "id": "f79x0y8c27a6m",
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  "landing_url": "https://doi.org/10.1016/j.jaccas.2026.110353",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Cardiac Amyloidosis"
    ],
    [
      "heading",
      "Clinical Case"
    ],
    [
      "lcc",
      "RC666-701"
    ],
    [
      "openalex",
      "2705|Cardiac Valve Diseases and Treatments"
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  "pdf_url": "https://europepmc.org/articles/PMC13699046?pdf=render",
  "pmcid": "PMC13699046",
  "pmid": "42910800",
  "published": "2026-10-01",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/f79x0y8c27a6m.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:43Z",
      "native_id": "PMC13699046",
      "source": "pmc",
      "url": "https://doi.org/10.1016/j.jaccas.2026.110353"
    },
    {
      "first_seen": "2026-10-30T12:20:14Z",
      "native_id": "MED:42910800",
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      "url": "https://europepmc.org/article/MED/42910800"
    },
    {
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      "url": "https://doi.org/10.1016/j.jaccas.2026.110353"
    }
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Cardiac Valve Diseases and Treatments",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Extremely Severe Aortic Stenosis Mimicking Cardiac Amyloidosis on Multimodality Imaging",
  "title_text": "Extremely Severe Aortic Stenosis Mimicking Cardiac Amyloidosis on Multimodality Imaging",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:43:15Z",
  "url": "https://research.draconitic.com/paper/f79x0y8c27a6m",
  "venue": "JACC Case Reports",
  "versions": []
}