{
  "abstract": "Introduction\n\nGeneralized Myasthenia gravis (gMG) is a rare autoimmune disorder of the neuromuscular junction caused by IgG autoantibodies against antigens in the postsynaptic cleft. This study aimed to assess the real-world effectiveness and safety of Efgartigimod (EFG) in AChR-positive gMG with overlapping autoimmune comorbidity.Methods\n\nEFG was administered as 4 consecutive weekly infusions or injections. Myasthenia Gravis Activity of Daily Living (MG-ADL) and Myasthenia Gravis quantitative (QMG) scales were administered at baseline and after 4 weeks. Clinical data on autoimmune comorbidities and prednisone use were collected.Results\n\n35 patients (20 women, mean age 53.6 years) received EFG, with a significant and clinical improvement in both MG-ADL and QMG scores. MG-ADL responder rate (MG-ADL reduction≥2) was 79%, while 68% on QMG (QMG reduction≥3); Minimal symptoms expression was reached in 4 patients, with a mean reduction in daily prednisone dose of 8 mg. Overlapping autoimmune comorbidity was reported in 12 gMG patients (34%). gMG patients with Stiff-Person syndrome, type 1 Diabetes and Lambert-Eaton myasthenic syndrome benefited more from EFG with a higher reduction on MG-ADL.Conclusion\n\nOverlapping autoimmune comorbidity is not rare. EFG demonstrated a meaningful clinical benefit in patients with AChR-positive gMG with overlapping IgG-mediated disorders.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Biomedicine, Neuroscience and Advanced Diagnostics (BiND), University of Palermo, Palermo, Italy.",
    "Neurology Unit, Department of Medicine, Surgery and Dentistry \"Scuola Medica Salernitana, Neuroscience Section, University Hospital \"San Giovanni di Dio e Ruggi d'Aragona, Salerno, Italy.",
    "IRCCS SYNLAB- SDN, Napoli, Italy.",
    "Neurology/Stroke Unit, Hospital A. Perrino, Brindisi, Italy."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 13,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Vincenzo Di Stefano"
    },
    {
      "affs": [
        0
      ],
      "name": "Nicasio Rini"
    },
    {
      "affs": [
        0
      ],
      "name": "Sofia Campo"
    },
    {
      "affs": [
        0
      ],
      "name": "Flora D'Amico"
    },
    {
      "affs": [
        0
      ],
      "name": "Aurora Meli"
    },
    {
      "affs": [
        0
      ],
      "name": "Simona Maccora"
    },
    {
      "affs": [
        0
      ],
      "name": "Filippo Brighina"
    },
    {
      "affs": [
        1
      ],
      "name": "Liliana Bevilacqua"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Paolo Barone"
    },
    {
      "affs": [
        3
      ],
      "name": "Alba Rosa Pati"
    },
    {
      "affs": [
        3
      ],
      "name": "Mariangela Ferrara"
    },
    {
      "affs": [
        3
      ],
      "name": "Augusto Maria Rini"
    },
    {
      "affs": [
        1
      ],
      "name": "Claudia Vinciguerra"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f7axcdq9q6vh9.bib",
  "cited_by": 0,
  "doi": "10.3389/fneur.2026.1919993",
  "fulltext_url": "https://europepmc.org/articles/PMC13680258",
  "id": "f7axcdq9q6vh9",
  "issns": [
    "1664-2295"
  ],
  "landing_url": "https://europepmc.org/article/MED/42903245",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Myasthenia Gravis and Thymoma"
    ]
  ],
  "openalex": "W7220696565",
  "pdf_url": "https://europepmc.org/articles/PMC13680258?pdf=render",
  "pmcid": "PMC13680258",
  "pmid": "42903245",
  "published": "2026-10-06",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/f7axcdq9q6vh9.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:57Z",
      "native_id": "MED:42903245",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42903245"
    },
    {
      "first_seen": "2026-10-30T12:20:16Z",
      "native_id": "10.3389/fneur.2026.1919993",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fneur.2026.1919993/full"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Myasthenia Gravis and Thymoma",
      "subfield": "neurology"
    }
  ],
  "title": "The effect of FcRn inhibition on overlapping autoimmune comorbidity in AChR-seropositive generalized myasthenia gravis.",
  "title_text": "The effect of FcRn inhibition on overlapping autoimmune comorbidity in AChR-seropositive generalized myasthenia gravis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:16Z",
  "url": "https://research.draconitic.com/paper/f7axcdq9q6vh9",
  "venue": "Frontiers in neurology",
  "versions": []
}