{
  "abstract": "Purpose: To assess the feasibility of an OCT-based radiomics approach in optic neuritis (ON) and determine whether peripapillary retinal nerve fiber layer (pRNFL) OCT-derived radiomic features could help differentiate between multiple sclerosis–associated ON (MS-ON) and myelin oligodendrocyte glycoprotein antibody–associated disease ON (MOGAD-ON).\n\nDesign: Retrospective cohort study.\n\nParticipants: Patients with ON associated with either MS (MS-ON) or MOGAD-ON were selected from the existing Optic Neuropathies of la Timone cohort. In total, 45 patients (61 eyes with ON; 28 with MS and 17 with MOGAD) contributing 266 OCT examinations were included.\n\nMethods: A radiomics pipeline was applied to pRNFL OCT data to extract quantitative imaging features. A total of 102 radiomic features were generated and reduced using feature selection methods. Unsupervised and supervised machine-learning approaches were used to identify relevant radiomic patterns and evaluate their ability to discriminate MS-ON from MOGAD-ON. Models were trained using radiomic features alone, clinical variables alone, and a combination of both.\n\nMain Outcome Measures: The primary outcome measure was the diagnostic performance of machine-learning models in distinguishing MS-ON from MOGAD-ON, assessed using the area under the receiver operating characteristic curve (AUC).\n\nResults: Among the 102 extracted radiomic features, 62 were retained after feature reduction, and 3 features were selected through machine-learning–based analysis. Supervised machine-learning models (logistic regression) using radiomic features outperformed models based on clinical variables alone (AUC, 0.763 vs. 0.584; P = 0.001). Combining radiomics with clinical variables yielded a numerically higher AUC of 0.788 than radiomics alone (0.763), but without statistical significance (P = 0.361). The combined model remained significantly better than the clinical-variable-only model (P < 0.001).\n\nConclusions: This study establishes a reproducible OCT radiomics pipeline and demonstrates the feasibility of applying unsupervised and supervised machine-learning approaches to pRNFL OCT data. Radiomic features show promising potential for improving the differentiation between MOGAD-ON and MS-ON.\n\nFinancial Disclosure(s): Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.",
  "abstract_shown": true,
  "affiliations": [
    "Aix Marseille Université, Centre d'Exploration Métabolique par Résonance Magnétique-Center for Magnetic Resonance in Biology and Medicine, Centre National de la Recherche Scientifique, Marseille, France",
    "Department of Ophthalmology, Assistance Publique Hôpitaux de Marseille, Hopital de la Conception, Marseille France",
    "Aix Marseille Université, Centre National de la Recherche Scientifique, Marseille, France",
    "Aix Marseille Université, Institut de Neurosciences de la Timone, Centre National de la Recherche Scientifique, Marseille, France",
    "Department of Neurology, Assistance Publique Hôpitaux de Marseille, Hopital de la Timone, Marseille, France",
    "Department of Radiology, Assistance Publique Hôpitaux de Marseille, Hopital de la Timone, Marseille, France"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 9,
  "authors": [
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        0
      ],
      "name": "Hoda El Mohyne"
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    {
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        2
      ],
      "name": "Thierry David"
    },
    {
      "affs": [
        1,
        3
      ],
      "name": "Kevin Mairot"
    },
    {
      "affs": [
        4
      ],
      "name": "Sarah Demortière"
    },
    {
      "affs": [
        0
      ],
      "name": "Shailesh Appukuttan"
    },
    {
      "affs": [
        1
      ],
      "name": "Mario Borrelli"
    },
    {
      "affs": [
        0,
        4
      ],
      "name": "Bertrand Audoin"
    },
    {
      "affs": [
        0,
        5
      ],
      "name": "Jan-Patrick Stellmann"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Natacha Stolowy"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f7bt8yzxs5aq3.bib",
  "cited_by": 0,
  "doi": "10.1016/j.xops.2026.101401",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13696368/",
  "id": "f7bt8yzxs5aq3",
  "issns": [
    "2666-9145"
  ],
  "landing_url": "https://doi.org/10.1016/j.xops.2026.101401",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Article"
    ],
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      "openalex",
      "2741|Radiomics and Machine Learning in Medical Imaging"
    ]
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  "openalex": "W7211879949",
  "pdf_url": "https://europepmc.org/articles/PMC13696368?pdf=render",
  "pmcid": "PMC13696368",
  "pmid": "42935570",
  "published": "2026-09-07",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/f7bt8yzxs5aq3.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:44Z",
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      "url": "https://doi.org/10.1016/j.xops.2026.101401"
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    {
      "first_seen": "2026-10-30T12:22:24Z",
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  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2741|Radiomics and Machine Learning in Medical Imaging",
      "subfield": "imaging"
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  ],
  "title": "OCT-Derived Radiomic Features for Differentiating Optic Neuritis Etiologies",
  "title_text": "OCT-Derived Radiomic Features for Differentiating Optic Neuritis Etiologies",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:33:43Z",
  "url": "https://research.draconitic.com/paper/f7bt8yzxs5aq3",
  "venue": "Ophthalmology Science",
  "versions": []
}