{
  "abstract": "Gastroesophageal reflux disease (GERD) is a common pediatric gastrointestinal disorder associated with significant morbidity, especially when persistent or severe. Although the primary underlying mechanism for GERD is lower esophageal sphincter dysfunction, there is accumulating evidence that disturbances in gastric motility significantly contribute. Described gastric motor abnormalities in GERD include delayed emptying, antral hypomotility, impaired gastric accommodation, abnormal intragastric meal distribution, disordered gastric myoelectrical activity, duodeno-gastro-esophageal reflux, and altered migrating motor complexes. These disturbances are hypothesized to contribute to GERD by increasing intragastric pressure, delaying gastric emptying, and facilitating retrograde flow of gastric contents into the esophagus, acting through complementary mechanisms. The relationship between gastric dysmotility and GERD symptoms remains unclear, leading to uncertainty regarding its clinical significance. Furthermore, there is uncertainty about the role of investigations such as gastric emptying scintigraphy, 13C-breath tests, and advanced motility techniques in routine practice. Therapeutic approaches for correcting motility disturbances, including prokinetic medications and neuromodulation, show promise but have limited evidence for their effectiveness in children. Future research should better delineate the role of gastric dysmotility in GERD, refine indications for gastric motility investigations, and evaluate the benefits of targeted motility-based therapies to optimize management strategies in pediatric GERD.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 2,
  "authors": [
    {
      "name": "Niranga Manjuri Devanarayana"
    },
    {
      "name": "Shaman Rajindrajith"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f8kezvn0a46j8.bib",
  "cited_by": 0,
  "doi": "10.5409/wjcp.122141",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13720612/",
  "id": "f8kezvn0a46j8",
  "issns": [
    "2219-2808"
  ],
  "landing_url": "https://doi.org/10.5409/wjcp.122141",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2715|Gastroesophageal reflux and treatments"
    ]
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  "openalex": "W7168190607",
  "pdf_url": "https://www.f6publishing.com/Forms/Main/DownloadFile.aspx?type=m&typeid=2&id=122141&filepath=8E31D0401EB18CD6271A9142AB7E05E301062559DD53F90DD88AB778F4FFE8640FA79464160D2D9A",
  "pmcid": "PMC13720612",
  "pmid": "42964452",
  "published": "2026-11-03",
  "publisher": "Baishideng Publishing Group Inc",
  "ris": "https://research.draconitic.com/paper/f8kezvn0a46j8.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T12:21:27Z",
      "native_id": "PMC13720612",
      "source": "pmc",
      "url": "https://doi.org/10.5409/wjcp.122141"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2715|Gastroesophageal reflux and treatments",
      "subfield": "general"
    }
  ],
  "title": "Gastric motility abnormalities in pediatric gastroesophageal reflux disease: A comprehensive review of mechanisms and therapeutic implications",
  "title_text": "Gastric motility abnormalities in pediatric gastroesophageal reflux disease: A comprehensive review of mechanisms and therapeutic implications",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T12:21:27Z",
  "url": "https://research.draconitic.com/paper/f8kezvn0a46j8",
  "venue": "World Journal of Clinical Pediatrics",
  "versions": []
}