{
  "abstract": "Background/Objectives: Adjuvant cell-based strategies are still being explored in amyotrophic lateral sclerosis (ALS). Materials and Methods: In this open-label, single-arm study of intrathecal autologous bone marrow-derived lineage-negative (LIN−) cells, we report functional status, quality of life, and survival after three administrations at six-week intervals. A total of 45 patients with sporadic ALS were qualified: 42 received all three administrations and 23 completed the 24-week assessment schedule, while 19 stopped attending because of deterioration. Results: In the 23 completers, Norris scale scores were stable until week 13 and then declined (p = 0.00004), and the Amyotrophic Lateral Sclerosis Assessment Questionnaire 40 (ALSAQ-40) followed the same pattern (p = 0.0019), whereas the ALS Functional Rating Scale—Revised (ALSFRS-R) declined at a constant 0.5 points per month. In all 42 treated patients the Norris score fell during treatment (0.95 points per month; 95% CI 0.52–1.38), so the plateau was confined to completers, who had milder baseline disease. Dose-related differences in quality of life were confounded by baseline imbalance; survival analyses were exploratory. Cell number did not correlate with cerebrospinal fluid brain-derived neurotrophic factor (BDNF) after the third administration in the 39 patients with paired samples (ρ = 0.14). No adverse event was recorded in 126 procedures, but harms were not graded systematically. Conclusions: These exploratory findings do not demonstrate efficacy; a sham-controlled trial with blinded raters is required.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, Pomeranian Medical University, 71-252 Szczecin, Poland",
    "Department of Hematology and Transplantology, Pomeranian Medical University, 71-252 Szczecin, Poland",
    "Department of General Pathology, Pomeranian Medical University, 70-111 Szczecin, Poland",
    "University Hospitals of Northamptonshire, Northampton General Hospital NHS Trust, Northampton NN1 5BD, UK",
    "Department of Pharmacology and Toxicology, University of Zielona Góra, 65-417 Zielona Góra, Poland"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 10,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Monika Gołąb-Janowska"
    },
    {
      "affs": [
        0
      ],
      "name": "Agnieszka Wełnicka-Wesołowska"
    },
    {
      "affs": [
        1
      ],
      "name": "Bartłomiej Baumert",
      "orcid": "0000-0001-9933-5844"
    },
    {
      "affs": [
        0
      ],
      "name": "Karolina Machowska-Sempruch"
    },
    {
      "affs": [
        0
      ],
      "name": "Agnieszka Meller",
      "orcid": "0000-0003-4075-1995"
    },
    {
      "affs": [
        2
      ],
      "name": "Anna Sobuś"
    },
    {
      "affs": [
        2
      ],
      "name": "Edyta Paczkowska",
      "orcid": "0000-0001-7052-9741"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Dariusz Kotlęga",
      "orcid": "0000-0002-3116-9656"
    },
    {
      "affs": [
        0
      ],
      "name": "Przemysław Nowacki"
    },
    {
      "affs": [
        1
      ],
      "name": "Bogusław Machaliński"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f8pcremra35jn.bib",
  "cited_by": 0,
  "doi": "10.3390/jcm15207937",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705995/?tool=EBI",
  "id": "f8pcremra35jn",
  "issns": [
    "2077-0383"
  ],
  "landing_url": "https://www.mdpi.com/2077-0383/15/20/7937",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2728|Amyotrophic Lateral Sclerosis Research"
    ]
  ],
  "openalex": "W7221761164",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13705995/pdf/?tool=EBI",
  "pmcid": "PMC13705995",
  "pmid": null,
  "published": "2026-10-01",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/f8pcremra35jn.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:00Z",
      "native_id": "10.3390/jcm15207937",
      "source": "crossref",
      "url": "https://www.mdpi.com/2077-0383/15/20/7937"
    },
    {
      "first_seen": "2026-10-30T12:21:40Z",
      "native_id": "PMC:PMC13705995",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13705995"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Amyotrophic Lateral Sclerosis Research",
      "subfield": "neurology"
    }
  ],
  "title": "Functional Status, Quality of Life and Survival After Repeated Intrathecal Administration of Autologous Lineage-Negative Cells in Amyotrophic Lateral Sclerosis",
  "title_text": "Functional Status, Quality of Life and Survival After Repeated Intrathecal Administration of Autologous Lineage-Negative Cells in Amyotrophic Lateral Sclerosis",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:21:40Z",
  "url": "https://research.draconitic.com/paper/f8pcremra35jn",
  "venue": "Journal of Clinical Medicine",
  "versions": []
}