{
  "abstract": "目的建立北京地区健康人群血清胃蛋白酶原Ⅰ（PGⅠ)、胃蛋白酶Ⅱ（PGⅡ）以及胃泌素-17（G-17）的参考区间。方法选取17 505名表观健康个体，采用荧光免疫层析法检测血清PGⅠ、PGⅡ和G-17水平并计算PGⅠ/PGⅡ比值。根据CLSI C28-A3文件，按照性别及年龄分组建立参考区间。结果17 505名表观健康个体血清PGⅠ、PGⅡ、PGⅠ/PGⅡ比值与G-17均呈偏态分布，采用百分位数法建立参考区间。Spearman相关性分析显示，PGⅠ、PGⅡ、PGⅠ/PGⅡ比值与年龄呈正相关（r值分别为0.24、0.17、0.25；均P<0.05）。男性组PGⅠ、PGⅡ、PGⅠ/PGⅡ比值均高于女性组（均P<0.05），而G-17低于女性组（P<0.05），需分性别建立参考区间。同性别不同年龄组PGⅠ、PGⅡ差异均有统计学意义（P<0.05），同性别≥60岁组分别与18~44岁组、45~59岁组PGⅠ/PGⅡ比值差异有统计学意义（P<0.05），进一步按照年龄建立参考区间，18~44岁PGⅠ：男、女分别是77.32~293.14 μg/L、67.90~262.10 μg/L；18~44岁PGⅡ：男、女分别是≤20.21 μg/L、≤21.19 μg/L；45~59岁PGⅠ：男、女分别是85.72~315.64 μg/L、73.17~282.42 μg/L；45~59岁PGⅡ：男、女分别是≤23.08 μg/L、≤23.23 μg/L；≥60岁PGⅠ：男、女分别是82.03~332.52 μg/L、78.10~300.74 μg/L；≥60岁PGⅡ：男、女分别是≤20.49 μg/L、≤20.81 μg/L；18~59岁PGⅠ/PGⅡ男、女分别是≥8.81、≥8.11；≥60岁PGⅠ/PGⅡ男、女分别是≥8.02、≥8.34。同性别不同年龄组G-17差异无统计学意义（P>0.05），可建立统一参考区间，男：1.04~35.17 pmol/L；女：1.31~35.04 pmol/L。结论本研究初步建立适合北京地区表观健康个体血清PGⅠ、PGⅡ、PGⅠ/PGⅡ比值以及G-17参考区间，为临床相关疾病的诊断提供实验参考依据。",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "陈泽慧"
    },
    {
      "name": "史一凡"
    },
    {
      "name": "张雅琴"
    },
    {
      "name": "申宝玲"
    },
    {
      "name": "钱树坤"
    },
    {
      "name": "刘建华"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f912rv3avdb3g.bib",
  "cited_by": 0,
  "doi": null,
  "fulltext_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.007",
  "id": "f912rv3avdb3g",
  "issns": [
    "1007-4287"
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  "landing_url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.007",
  "language": "zh",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RB1-214"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-24",
  "publisher": "Editorial Office of Chinese Journal of Laboratory Diagnosis",
  "ris": "https://research.draconitic.com/paper/f912rv3avdb3g.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:44:44Z",
      "native_id": "3dda3f013b1f4588a79482866e84e6ef",
      "source": "doaj",
      "url": "http://zszd.publish.founderss.cn/thesisDetails#10.3969/j.issn.1007-4287.2026.10.007"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RB1-214",
      "subfield": "general"
    }
  ],
  "title": "北京地区健康人群血清胃蛋白酶原与胃泌素-17参考区间的建立",
  "title_text": "北京地区健康人群血清胃蛋白酶原与胃泌素-17参考区间的建立",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:44Z",
  "url": "https://research.draconitic.com/paper/f912rv3avdb3g",
  "venue": "Zhongguo shiyan zhenduanxue",
  "versions": []
}