{
  "abstract": "OBJECTIVE: This study aimed to investigate the effects of breaking up sedentary behavior (SB) on daily movement behavior and energy balance in adults with overweight/obesity. METHODS: ) were randomized to either BREAK (multiple 5-min brisk walking bouts) or a duration-matched intervention, ONE (45-min brisk walking), performed 5 days/week for 6 weeks. At pre- and post-intervention, daily SB and physical activity (PA; accelerometry), body composition (doubly labeled water [DLW]), total daily energy expenditure (TDEE; DLW), appetite, and fasting leptin were measured. Linear mixed-effects models tested time effects and group-by-time interactions. RESULTS: Only BREAK reduced prolonged SB (interaction: p = 0.043). Both groups shifted SB-PA composition toward greater moderate-to-vigorous PA, with proportional reductions in SB and light PA (time: all p ≤ 0.011). These changes in PA level were associated with increased TDEE (time: p = 0.040). ONE showed small increases in body and fat mass compared with BREAK (interaction: both p ≤ 0.061). No differences were noted in metabolizable energy intake, appetite, or leptin levels. CONCLUSIONS: Spreading short PA bouts throughout the day increases moderate-to-vigorous PA and TDEE to the same extent as a traditional continuous PA bout. Future studies should investigate whether the modest body composition changes observed across interventions are driven by distinct behavioral/physiological compensations influenced by the daily pattern of PA/SB. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02998892.",
  "abstract_shown": true,
  "affiliations": [
    "Division of Endocrinology, Metabolism and Diabetes, Anschutz Health and Wellness Center, Department of Medicine, School of Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA",
    "Faculty of Applied Sciences State University of Campinas Limeira São Paulo Brazil",
    "Institut Pluridisciplinaire Hubert Curien, UMR7178 Centre National de la Recherche Scientifique, Université de Strasbourg Strasbourg France",
    "Section of Endocrinology, Department of Pediatrics, School of Medicine University of Colorado Anschutz Medical Campus Aurora Colorado USA",
    "CarMeN Laboratory INSERM 1060, INRA 1397, University Claude Bernard Lyon 1, Human Nutrition Research Center Rhône‐Alpes Oullins France"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Heloisa C. Santo Andre",
      "orcid": "0000-0001-9177-7410"
    },
    {
      "affs": [
        2
      ],
      "name": "Elisa Le Roux"
    },
    {
      "affs": [
        0
      ],
      "name": "Nathan P. De Jong"
    },
    {
      "affs": [
        0
      ],
      "name": "Patricia R. Smith"
    },
    {
      "affs": [
        0
      ],
      "name": "Andrew H. Lange"
    },
    {
      "affs": [
        0
      ],
      "name": "Carlos Mendez"
    },
    {
      "affs": [
        2
      ],
      "name": "Alexandre Zahariev"
    },
    {
      "affs": [
        0
      ],
      "name": "Melissa L. Mamele"
    },
    {
      "affs": [
        0
      ],
      "name": "Ginger Johnson"
    },
    {
      "affs": [
        3
      ],
      "name": "Zhaoxing Pan"
    },
    {
      "affs": [
        4
      ],
      "name": "Chantal Simon"
    },
    {
      "affs": [
        0
      ],
      "name": "Daniel H. Bessesen"
    },
    {
      "affs": [
        0
      ],
      "name": "Ana J. Pinto"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Audrey Bergouignan"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f953qd4364c06.bib",
  "cited_by": 0,
  "doi": "10.1002/oby.70310",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13716192/",
  "id": "f953qd4364c06",
  "issns": [
    "1930-7381",
    "1930-739X"
  ],
  "landing_url": "https://hal.science/hal-05798251v1",
  "language": "en",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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    [
      "heading",
      "Clinical Trials and Investigations"
    ],
    [
      "heading",
      "ORIGINAL ARTICLE"
    ],
    [
      "heading",
      "Original Article"
    ],
    [
      "openalex",
      "2737|Physical Activity and Health"
    ]
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  "openalex": "W7220705112",
  "pdf_url": "https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/oby.70310",
  "pmcid": "PMC13716192",
  "pmid": "42838926",
  "published": "2026-10-06",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/f953qd4364c06.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:56Z",
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      "url": "https://hal.science/hal-05798251v1"
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    {
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      "native_id": "PMC13716192",
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  "subjects": [
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      "origin": "openalex:2737|Physical Activity and Health",
      "subfield": "physiology"
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  ],
  "title": "Frequent Versus Single Active Bouts Differentially Affect Movement Behavior and Energy Balance in Adults With Overweight/Obesity",
  "title_text": "Frequent Versus Single Active Bouts Differentially Affect Movement Behavior and Energy Balance in Adults With Overweight/Obesity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:14Z",
  "url": "https://research.draconitic.com/paper/f953qd4364c06",
  "venue": "Obesity",
  "versions": []
}