{
  "abstract": "Similar dietary isoflavone intakes need not generate similar metabolite exposures. Gut microbiota-dependent conversion of daidzein to S-equol offers a plausible, incompletely characterized modifier of pediatric endocrine responses. Pediatric observational data suggest that urinary equol may modify associations between soy intake and pubertal timing, although causality and a fixed producer phenotype have not been established. We propose treating equol-producing capacity as a developmentally dynamic metabotype and testing it through repeated functional phenotyping. Receptor-selective effects on pubertal signaling and interactions with iodine-dependent thyroid physiology remain hypotheses with unknown clinical direction. Prospective studies should integrate diet, functional metabolism, developmental stage, iodine assessment and endocrine outcomes. Current evidence does not justify equol-based dietary restriction or routine clinical testing in healthy children.",
  "abstract_shown": true,
  "affiliations": [
    "Hebei University of Chinese Medicine, Shijiazhuang, China",
    "The Second Hospital of Hebei Medical University, Shijiazhuang, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ruiying Fan"
    },
    {
      "affs": [
        1
      ],
      "name": "Yutong Xing"
    },
    {
      "affs": [
        1
      ],
      "name": "Kaixi Wang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xinyu Ma"
    },
    {
      "affs": [
        1
      ],
      "name": "Huifeng Zhang"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f9ajq41tahvym.bib",
  "cited_by": 0,
  "doi": "10.3389/fnut.2026.1993262",
  "fulltext_url": "https://www.frontiersin.org/articles/10.3389/fnut.2026.1993262/full",
  "id": "f9ajq41tahvym",
  "issns": [
    "2296-861X"
  ],
  "landing_url": "https://doi.org/10.3389/fnut.2026.1993262",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "TX341-641"
    ],
    [
      "openalex",
      "2734|Phytoestrogen effects and research"
    ]
  ],
  "openalex": "W7223696350",
  "pdf_url": "https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1993262/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-26",
  "publisher": "Frontiers Media S.A.",
  "ris": "https://research.draconitic.com/paper/f9ajq41tahvym.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:47:19Z",
      "native_id": "41eeea30d7634327a4b5cc2ac89ee8fa",
      "source": "doaj",
      "url": "https://doi.org/10.3389/fnut.2026.1993262"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:TX341-641",
      "subfield": "nutrition"
    }
  ],
  "title": "Equol-producing capacity as an overlooked modifier of pediatric isoflavone responses",
  "title_text": "Equol-producing capacity as an overlooked modifier of pediatric isoflavone responses",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:47:19Z",
  "url": "https://research.draconitic.com/paper/f9ajq41tahvym",
  "venue": "Frontiers in Nutrition",
  "versions": []
}