{
  "abstract": "Conventional adenomas and serrated lesions are two major precursor lesions of colorectal cancer. They arise through distinct carcinogenic pathways, namely the conventional adenoma–carcinoma sequence and the serrated neoplasia pathway. These pathways differ substantially in their underlying molecular mechanisms, implying that the risk factor profiles for the two types of lesions may be different. However, existing evidence remains fragmented, and an integrated comparative synthesis of these differential associations is lacking. In this review, we synthesize and compare current evidence on the mechanistic characteristics and lifestyle, metabolic, and nutritional determinants of conventional adenomas and serrated lesions. By synthesizing the available evidence on the two precursor pathways, this review may contribute to a better understanding of conventional adenomas and serrated lesions, and offer insights for future research into their distinct risk factors, underlying mechanisms, and implications for colorectal cancer prevention.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Epidemiology and Biostatistics, School of Public Health and Nursing, Hangzhou Normal University",
    "Department of Nutrition and Toxicology, School of Public Health and Nursing, Hangzhou Normal University"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Junjie Cai"
    },
    {
      "affs": [
        0
      ],
      "name": "Yiliu Huang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yi Luo"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui Zeng"
    },
    {
      "affs": [
        1
      ],
      "name": "Jun Yang"
    },
    {
      "affs": [
        0
      ],
      "name": "Yingshuang Zhu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/f9bcrzd390d0c.bib",
  "cited_by": 0,
  "doi": "10.3389/fpubh.2026.1949376",
  "fulltext_url": "https://europepmc.org/articles/PMC13715656",
  "id": "f9bcrzd390d0c",
  "issns": [
    "2296-2565"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1949376/full",
  "language": "eng",
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2730|Colorectal Cancer Screening and Detection"
    ]
  ],
  "openalex": "W7221819212",
  "pdf_url": "https://www.frontiersin.org/journals/public-health/articles/10.3389/fpubh.2026.1949376/pdf",
  "pmcid": "PMC13715656",
  "pmid": "42953785",
  "published": "2026-10-14",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/f9bcrzd390d0c.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:22Z",
      "native_id": "10.3389/fpubh.2026.1949376",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fpubh.2026.1949376/full"
    },
    {
      "first_seen": "2026-10-31T00:20:41Z",
      "native_id": "MED:42953785",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953785"
    },
    {
      "first_seen": "2026-11-01T12:22:53Z",
      "native_id": "PMC13715656",
      "source": "pmc",
      "url": "https://doi.org/10.3389/fpubh.2026.1949376"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2730|Colorectal Cancer Screening and Detection",
      "subfield": "oncology"
    }
  ],
  "title": "Differential risk and protective factors for conventional adenomas and serrated lesions: implications for colorectal cancer prevention",
  "title_text": "Differential risk and protective factors for conventional adenomas and serrated lesions: implications for colorectal cancer prevention",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:22:53Z",
  "url": "https://research.draconitic.com/paper/f9bcrzd390d0c",
  "venue": "Frontiers in Public Health",
  "versions": []
}