{
  "abstract": "Objective This study investigated the expression, prognostic significance, and functional role of α‐L‐iduronidase (IDUA) in clear cell renal cell carcinoma (ccRCC). Methods We performed two‐sample Mendelian randomization using eQTL and ccRCC GWAS data. We analyzed transcriptomic and clinical data from TCGA and GEO cohorts. We constructed a prognostic nomogram integrating IDUA expression with clinicopathological variables. We used ESTIMATE and CIBERSORT algorithms to evaluate immune infiltration and examined correlations between IDUA and immune checkpoint genes. We knocked down IDUA in 786‐O and ACHN cells using shRNA and assessed proliferation, invasion, and migration via MTT, Transwell, and wound‐healing assays. Results IDUA was significantly overexpressed in ccRCC tumors versus normal tissues. High IDUA expression correlated with advanced stage, higher T stage, and poor overall survival. Multivariate Cox regression confirmed IDUA as an independent prognostic factor (HR = 1.614, p < 0.001). The nomogram showed good predictive performance for 1‐, 3‐, and 5‐year survival. IDUA expression positively correlated with immune checkpoint genes (PDCD1, CD274, CTLA4) and with infiltration of CD8+ T cells, Tregs, and activated NK cells. High IDUA predicted higher Immunophenoscores, suggesting better immunotherapy response. In vitro, IDUA knockdown significantly reduced ccRCC cell proliferation, invasion, and migration. Conclusion IDUA serves as an independent prognostic biomarker in ccRCC, promotes tumor aggressiveness, and may modulate the immune microenvironment. These findings support IDUA as a potential therapeutic target and a candidate predictor for immunotherapy response in ccRCC.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Urology Peking University Shenzhen Hospital Shenzhen China",
    "The Second Affiliated Hospital of Anhui Medical University Hefei China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Zhangjun Cao"
    },
    {
      "affs": [
        0
      ],
      "name": "Songbai Yan"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenhao Chu"
    },
    {
      "affs": [
        0
      ],
      "name": "Haichao Yuan"
    },
    {
      "affs": [
        0
      ],
      "name": "Zefeng Shen"
    },
    {
      "affs": [
        0
      ],
      "name": "Liangkuan Bi"
    },
    {
      "affs": [
        1
      ],
      "name": "Longfei Peng"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fa5f5svtf02f7.bib",
  "cited_by": 0,
  "doi": "10.1002/cam4.72347",
  "fulltext_url": "https://doi.org/10.1002/cam4.72347",
  "id": "fa5f5svtf02f7",
  "issns": [
    "2045-7634"
  ],
  "landing_url": "https://doi.org/10.1002/cam4.72347",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "lcc",
      "RC254-282"
    ]
  ],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-09",
  "publisher": "Wiley",
  "ris": "https://research.draconitic.com/paper/fa5f5svtf02f7.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T14:21:36Z",
      "native_id": "0fa71e1991df4d00af70992e7e09e8b5",
      "source": "doaj",
      "url": "https://doi.org/10.1002/cam4.72347"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "lcc:RC254-282",
      "subfield": "oncology"
    }
  ],
  "title": "Identification of the Glycosaminoglycan Metabolism‐Related Protein IDUA Associated With Tumor Progression and Prognosis in ccRCC",
  "title_text": "Identification of the Glycosaminoglycan Metabolism‐Related Protein IDUA Associated With Tumor Progression and Prognosis in ccRCC",
  "type": "peer-reviewed",
  "updated_at": "2026-11-09T14:21:36Z",
  "url": "https://research.draconitic.com/paper/fa5f5svtf02f7",
  "venue": "Cancer Medicine",
  "versions": []
}