{
  "abstract": "Introduction\n\nEndovascular thrombectomy (EVT) is established for large infarcts, but remains cautiously applied in extensive infarcts with an Alberta Stroke Program Early CT Score (ASPECTS) of 0-2. Real-life outcome data remain limited.Patients and methods\n\nRetrospective analysis of the German Stroke Registry-Endovascular Treatment comparing extensive (ASPECTS 0-2) and large infarcts (ASPECTS 3-5) in patients with anterior-circulation occlusion and EVT. The primary outcome was the ordinal 90-day mRS distribution; secondary outcomes were mRS 0-3, survival, quality of life (3-level European Quality of Life-5 Dimensions) and living condition.Results\n\nOf 18,069 screened patients, 889 were analysed (ASPECTS 1-2, n = 89; ASPECTS 3-5, n = 800); none had ASPECTS 0. With ASPECTS 1-2, 20.2% achieved mRS 0-3 and 55.1% died within 90 days. In the model including successful reperfusion, no statistically significant association was detected between infarct group and the 90-day mRS distribution (common odds ratio [cOR] 0.80; 95% CI, 0.53-1.23) or mRS 0-3 (adjusted odds ratio [aOR] 0.89; 95% CI, 0.64-1.25), whereas successful reperfusion was associated with both (cOR 3.68; 95% CI, 2.31-5.85 and aOR 4.10; 95% CI, 2.45-6.86). Among survivors, median European Quality of Life-5 Dimensions utility index was 0.445 vs 0.541 (n = 27/324), and 51.5% vs 50.9% lived at home (n = 33/411).Discussion\n\nAn extensive infarct carried a challenging prognosis, yet acceptable outcome and non-institutional living remained achievable in a relevant minority. An independent association of infarct group with outcome was not detected.Conclusion\n\nAn acceptable outcome remained attainable in selected patients with extensive infarction, particularly after successful reperfusion. Lacking a medically managed comparator, these data describe prognosis rather than treatment effect.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Vascular Neurology, University Hospital Bonn, Bonn, Germany.",
    "German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany.",
    "Department of Neuroimmunology, University Hospital Bonn, Bonn, Germany.",
    "Department of Neuroradiology, University Hospital Bonn, Bonn, Germany.",
    "Department of Neurooncology, University Hospital Bonn, Bonn, Germany."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
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        0,
        1
      ],
      "name": "Hannah Asperger",
      "orcid": "0000-0003-3253-7016"
    },
    {
      "affs": [
        0
      ],
      "name": "Felix J Bode",
      "orcid": "0000-0003-4498-186X"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Taraneh Ebrahimi",
      "orcid": "0000-0002-5471-4266"
    },
    {
      "affs": [
        0
      ],
      "name": "Lara Klehr",
      "orcid": "0009-0008-3429-8198"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Julia Layer",
      "orcid": "0000-0001-5904-5316"
    },
    {
      "affs": [
        0
      ],
      "name": "Julius Meißner",
      "orcid": "0000-0002-8980-9337"
    },
    {
      "affs": [
        0,
        2
      ],
      "name": "Louisa Nitsch",
      "orcid": "0000-0002-5139-6848"
    },
    {
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        0,
        1
      ],
      "name": "Omid Shirvani",
      "orcid": "0009-0006-6367-8742"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Christian S Thielscher",
      "orcid": "0000-0002-7109-4820"
    },
    {
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        0,
        1
      ],
      "name": "Niklas M von Danwitz",
      "orcid": "0000-0003-3263-369X"
    },
    {
      "affs": [
        3
      ],
      "name": "Svenja Odensaß",
      "orcid": "0009-0003-0857-528X"
    },
    {
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        0
      ],
      "name": "Sebastian Stösser",
      "orcid": "0000-0002-1182-705X"
    },
    {
      "affs": [
        3
      ],
      "name": "Franziska Dorn",
      "orcid": "0000-0001-9093-8307"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Gabor C Petzold",
      "orcid": "0000-0002-0145-8641"
    },
    {
      "affs": [
        0,
        2,
        4
      ],
      "name": "Johannes Weller",
      "orcid": "0000-0001-5818-5392"
    },
    {
      "name": "GSR-ET Investigators"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fagt4vwdk0kqh.bib",
  "cited_by": 0,
  "doi": "10.1093/esj/aakag131",
  "fulltext_url": "https://europepmc.org/articles/PMC13725919",
  "id": "fagt4vwdk0kqh",
  "issns": [
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  "landing_url": "https://europepmc.org/article/MED/42969847",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
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      "2713|Acute Ischemic Stroke Management"
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  "pdf_url": "https://europepmc.org/articles/PMC13725919?pdf=render",
  "pmcid": "PMC13725919",
  "pmid": "42969847",
  "published": "2026-11-01",
  "publisher": "Oxford University Press",
  "ris": "https://research.draconitic.com/paper/fagt4vwdk0kqh.ris",
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      "field": "medicine",
      "origin": "openalex:2713|Acute Ischemic Stroke Management",
      "subfield": "epidemiology-public-health"
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  ],
  "title": "Functional outcomes and quality of life after endovascular thrombectomy in large and extensive infarcts (ASPECTS 0-5): a multicentre registry study.",
  "title_text": "Functional outcomes and quality of life after endovascular thrombectomy in large and extensive infarcts (ASPECTS 0-5): a multicentre registry study.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:21:59Z",
  "url": "https://research.draconitic.com/paper/fagt4vwdk0kqh",
  "venue": "European stroke journal",
  "versions": []
}