{
  "abstract": "Introduction\n\nSystemic isotretinoin is extensively used to treat moderate-to-severe acne vulgaris and may have systemic endocrine effects through the hypothalamic-pituitary-thyroid axis.Objectives\n\nTo investigate the changes in thyroid hormone levels after commencement of systemic isotretinoin among patients with acne vulgaris.Methods\n\nA PubMed, ScienceDirect, Scopus, and Cochrane Library search was performed. Pooled analysis was conducted utilizing Review Manager (RevMan 5.4.1).Results\n\nA total of 447 patients from eight observational studies were included. After three and four months, no increase in TSH levels was observed following isotretinoin treatment with a standardized mean difference (SMD) of 0.09 (95% CI: -0.27-0.46; P=0.62) and (SMD=0.72; 95% CI: -0.01-1.45; P>0.05), respectively. However, a significant increase in TSH levels was observed at six months (SMD=0.54; 95% CI: 0.05-1.03; P=0.03). T4 levels showed no alteration at three months (SMD= -0.24; 95% CI: -0.56-0.08; P=0.14) but were reduced at four months (SMD= -0.79; 95% CI: -1.20--0.38; P=0.0001) and six months (SMD= -0.87; 95% CI: -1.57--0.17; P=0.01). T3 levels were reduced at three months (SMD= -0.42; 95% CI: -0.80--0.04; P=0.03), four months (SMD=-0.63; 95% CI: -1.03--0.23; P=0.002), and 6 months (SMD= -1.13; 95% CI: -1.77--0.55; P=0.0001).Conclusion\n\nLong-term isotretinoin treatment may cause time-dependent changes in thyroid hormone levels.",
  "abstract_shown": true,
  "affiliations": [
    "College of Medicine, King Saud Bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia.",
    "College of Medicine, King Faisal University, Al-Ahsa, Saudi Arabia.",
    "College of Medicine, King Saud University, Riyadh, Saudi Arabia.",
    "Department of Pediatric Dermatology, King Abdulaziz Medical City, Riyadh, Saudi Arabia."
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Mishari Tariq Alrubaiaan"
    },
    {
      "affs": [
        1
      ],
      "name": "Ajlan Hashim Alajlani"
    },
    {
      "affs": [
        2
      ],
      "name": "Raneem Alwatban"
    },
    {
      "affs": [
        1
      ],
      "name": "Abdulelah Nabil Alkadi"
    },
    {
      "affs": [
        0
      ],
      "name": "Hawra Fahad Alkhodairy"
    },
    {
      "affs": [
        0
      ],
      "name": "Fatimah Moayed Alalwan"
    },
    {
      "affs": [
        0
      ],
      "name": "Sarah Waleed Bin Rashid"
    },
    {
      "affs": [
        3
      ],
      "name": "Waleed Alajroush"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fajdehs14np54.bib",
  "cited_by": 0,
  "doi": "10.5826/dpc.1603a7403",
  "fulltext_url": "https://europepmc.org/articles/PMC13557271",
  "id": "fajdehs14np54",
  "issns": [
    "2160-9381"
  ],
  "landing_url": "https://europepmc.org/article/MED/42858442",
  "language": "eng",
  "licence": "CC-BY-NC",
  "licence_label": "CC BY-NC",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2708|Acne and Rosacea Treatments and Effects"
    ]
  ],
  "openalex": "W7172019796",
  "pdf_url": "https://europepmc.org/articles/PMC13557271?pdf=render",
  "pmcid": "PMC13557271",
  "pmid": "42858442",
  "published": "2026-07-31",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fajdehs14np54.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:19:18Z",
      "native_id": "MED:42858442",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42858442"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2708|Acne and Rosacea Treatments and Effects",
      "subfield": "general"
    }
  ],
  "title": "Impact of Isotretinoin Therapy on Thyroid Hormone Levels in Patients with Acne Vulgaris: A Systematic Review and Meta-Analysis.",
  "title_text": "Impact of Isotretinoin Therapy on Thyroid Hormone Levels in Patients with Acne Vulgaris: A Systematic Review and Meta-Analysis.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:18Z",
  "url": "https://research.draconitic.com/paper/fajdehs14np54",
  "venue": "Dermatology practical & conceptual",
  "versions": []
}