{
  "abstract": "Autoimmune disease may arise from disruptions in immune architecture rather than isolated molecular defects. High-dimensional immunology now reveals dynamic cellular states, regulatory circuits, and tissue-specific immune niches, but translation into therapy remains limited. We propose an Architecture-Anomaly-Target-Lead framework that contextualises therapeutic targets within immune organisation and complements Reset-Rebuild strategies. Together, these concepts provide a framework for developing and evaluating more sustained, tolerance-focused treatment approaches for autoimmune disease.",
  "abstract_shown": true,
  "affiliations": [
    "Translational Immunology Institute, SingHealth/Duke-NUS Academic Medical Centre, Singapore, Singapore",
    "Duke-NUS Medical School, Singapore, Singapore"
  ],
  "article_type": "review article",
  "arxiv": null,
  "author_total": 3,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Vasuki-Ranjani Chellamuthu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yunqian Zhao"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Salvatore Albani"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fav0z0qvcjh9c.bib",
  "cited_by": 0,
  "doi": "10.1038/s44483-026-00007-0",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13723410/",
  "id": "fav0z0qvcjh9c",
  "issns": [
    "3091-2792"
  ],
  "landing_url": "https://doi.org/10.1038/s44483-026-00007-0",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Review"
    ],
    [
      "openalex",
      "2403|T-cell and B-cell Immunology"
    ]
  ],
  "openalex": "W7225002490",
  "pdf_url": "https://www.nature.com/articles/s44483-026-00007-0.pdf",
  "pmcid": "PMC13723410",
  "pmid": "42973447",
  "published": "2026-10-31",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fav0z0qvcjh9c.ris",
  "sources": [
    {
      "first_seen": "2026-11-04T12:22:03Z",
      "native_id": "PMC13723410",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s44483-026-00007-0"
    },
    {
      "first_seen": "2026-11-05T03:20:59Z",
      "native_id": "MED:42973447",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42973447"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|T-cell and B-cell Immunology",
      "subfield": "immunology"
    }
  ],
  "title": "High-dimensionality approaches to the understanding and therapeutic manipulation of autoimmunity",
  "title_text": "High-dimensionality approaches to the understanding and therapeutic manipulation of autoimmunity",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:14Z",
  "url": "https://research.draconitic.com/paper/fav0z0qvcjh9c",
  "venue": "Npj Autoimmunity",
  "versions": []
}