{
  "abstract": "Parkinson’s disease involves progressive α-synuclein pathology, but how this reshapes the brain’s spatial immunometabolic landscape, and how oligodendrocytes participate, remain incompletely defined. Here we combine single-nucleus RNA sequencing, spatial transcriptomics and spatial metabolomics in male A53T α-synuclein transgenic mice across disease stages, together with male mice carrying adeno-associated virus-mediated α-synuclein overexpression, human midbrain and cerebrospinal fluid samples. We describe a disease-associated oligodendrocyte lineage marked by elevated Il33 and Kirrel3 that expands with pathology in both mouse models. Interleukin 33 is upregulated in oligodendrocytes and its receptor ST2 in microglia, and bidirectional manipulation of oligodendrocyte Il33 alters microglial ST2 activation, insoluble α-synuclein burden and motor performance. In the substantia nigra and ventral tegmental area, transcriptomic and metabolomic changes converge on lipid- and glutamate-related pathways. Both proteins are also elevated in human Parkinson’s disease midbrain and cerebrospinal fluid. These data implicate oligodendrocyte interleukin 33–ST2 signalling and provide a spatially resolved resource.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Neurology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510120 China",
    "School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, 511436 China",
    "State Key Laboratory of Respiratory Disease, Guangzhou Medical University, Guangzhou, 511436 China",
    "Guangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Degradation, Guangzhou Medical University, Guangzhou, 511436 China",
    "The Second Affiliated Hospital of Xinjiang Medical University, Urumqi, 830054 Xinjiang China",
    "Department of Neurology, the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021 China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 14,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Ziting Zhu",
      "orcid": "0000-0002-0662-205X"
    },
    {
      "affs": [
        0
      ],
      "name": "Zongtang Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Minshan Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Liuyan Ding"
    },
    {
      "affs": [
        1,
        2,
        3
      ],
      "name": "Du Feng",
      "orcid": "0000-0002-2489-4702"
    },
    {
      "affs": [
        0
      ],
      "name": "Fengchu Liang"
    },
    {
      "affs": [
        0
      ],
      "name": "Hui Shu"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhongqiang Su"
    },
    {
      "affs": [
        4
      ],
      "name": "Xingting Huang"
    },
    {
      "affs": [
        1
      ],
      "name": "Xiaoqin Zhu"
    },
    {
      "affs": [
        0
      ],
      "name": "Xiaolei Liang"
    },
    {
      "affs": [
        5
      ],
      "name": "Shuxuan Huang",
      "orcid": "0009-0006-3058-8601"
    },
    {
      "affs": [
        0
      ],
      "name": "Pingyi Xu"
    },
    {
      "affs": [
        0
      ],
      "name": "Wenlong Zhang",
      "orcid": "0000-0002-2402-0685"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fbcmy9w3qqh33.bib",
  "cited_by": 0,
  "doi": "10.1038/s41467-026-78051-5",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13710843/",
  "id": "fbcmy9w3qqh33",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-78051-5",
  "language": "en",
  "licence": "CC-BY-NC-ND-4.0",
  "licence_label": "CC BY-NC-ND 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Article"
    ],
    [
      "openalex",
      "2728|Parkinson's Disease Mechanisms and Treatments"
    ]
  ],
  "openalex": "W7214384721",
  "pdf_url": "https://www.nature.com/articles/s41467-026-78051-5_reference.pdf",
  "pmcid": "PMC13710843",
  "pmid": "42934224",
  "published": "2026-09-25",
  "publisher": "Nature Publishing Group",
  "ris": "https://research.draconitic.com/paper/fbcmy9w3qqh33.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T12:21:43Z",
      "native_id": "PMC13710843",
      "source": "pmc",
      "url": "https://doi.org/10.1038/s41467-026-78051-5"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2728|Parkinson's Disease Mechanisms and Treatments",
      "subfield": "neurology"
    }
  ],
  "title": "Spatial multi-omics reveals disease-associated oligodendrocytes and metabolic dysregulation in male Parkinson’s disease mouse models",
  "title_text": "Spatial multi-omics reveals disease-associated oligodendrocytes and metabolic dysregulation in male Parkinson’s disease mouse models",
  "type": "peer-reviewed",
  "updated_at": "2026-10-31T12:21:43Z",
  "url": "https://research.draconitic.com/paper/fbcmy9w3qqh33",
  "venue": "Nature Communications",
  "versions": []
}