{
  "abstract": "Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging tick-borne viral disease associated with substantial mortality. Renal dysfunction and coagulation abnormalities are closely related to disease severity. This study aimed to evaluate the prognostic significance of the blood urea nitrogen-to-fibrinogen ratio (BUN/FIB) in patients with SFTS.\n\nMethods: This single-center retrospective cohort study included adult patients with laboratory-confirmed SFTS admitted to the First Affiliated Hospital of the University of Science and Technology of China between June 2020 and June 2025. Admission BUN/FIB was calculated using BUN and fibrinogen values. Logistic regression, receiver operating characteristic (ROC) analysis, survival analysis, and paired-sample analysis were performed to evaluate the association between BUN/FIB and 30-day all-cause mortality.\n\nResults: Of the 475 patients, 378 (79.6%) survived and 97 (20.4%) died. Admission BUN/FIB levels were significantly higher in non-survivors than in survivors. Multivariable logistic regression identified older age, neurological signs, higher C-reactive protein, higher Ct-derived SFTSV RNA burden, and higher BUN/FIB (OR: 1.565; 95% CI: 1.348–1.851; P<0.001) as independently associated with 30-day mortality. BUN/FIB showed an apparent AUC of 0.835 (95% CI: 0.791–0.880), with a cohort-derived cut-off of 3.312 mmol/g. This threshold showed a sensitivity of 78.4% and specificity of 78.0% but requires external validation. BUN/FIB showed higher apparent discrimination than conventional inflammatory indices and comparable apparent discrimination with Ct-derived SFTSV RNA burden. Higher BUN/FIB was associated with poorer survival. In paired analyses, BUN/FIB decreased among survivors and increased among non-survivors.\n\nConclusion: Admission BUN/FIB was independently associated with 30-day mortality and showed favorable apparent discriminatory performance in this retrospective cohort. BUN/FIB may serve as a candidate adjunctive prognostic marker, but its optimal threshold, clinical utility, and generalizability require validation in prospective multicenter studies.",
  "abstract_shown": true,
  "affiliations": [
    "The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230000, People’s Republic of China"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Ling-Han Qin"
    },
    {
      "affs": [
        0
      ],
      "name": "Jing Wu",
      "orcid": "0000-0003-1931-4678"
    },
    {
      "affs": [
        0
      ],
      "name": "Ting Liu"
    },
    {
      "affs": [
        0
      ],
      "name": "Ye Li"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu-Ru Shi"
    },
    {
      "affs": [
        0
      ],
      "name": "Ying-Jie Qi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fbdfkfp8cc7py.bib",
  "cited_by": 0,
  "doi": "10.2147/idr.s634788",
  "fulltext_url": "https://pmc.ncbi.nlm.nih.gov/articles/PMC13729853/",
  "id": "fbdfkfp8cc7py",
  "issns": [
    "1178-6973"
  ],
  "landing_url": "https://doi.org/10.2147/idr.s634788",
  "language": "en",
  "licence": "CC-BY-NC-4.0",
  "licence_label": "CC BY-NC 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by-nc/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Original Research"
    ],
    [
      "openalex",
      "2725|Viral Infections and Vectors"
    ]
  ],
  "openalex": "W7224621138",
  "pdf_url": "https://www.dovepress.com/article/download/121588",
  "pmcid": "PMC13729853",
  "pmid": "42979168",
  "published": "2026-10-30",
  "publisher": "Dove Press",
  "ris": "https://research.draconitic.com/paper/fbdfkfp8cc7py.ris",
  "sources": [
    {
      "first_seen": "2026-11-07T12:22:35Z",
      "native_id": "PMC13729853",
      "source": "pmc",
      "url": "https://doi.org/10.2147/idr.s634788"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2725|Viral Infections and Vectors",
      "subfield": "infectious-disease"
    }
  ],
  "title": "Prognostic Value of the Blood Urea Nitrogen-to-Fibrinogen Ratio for 30-Day Mortality in Patients with Severe Fever with Thrombocytopenia Syndrome: A Single-Center Retrospective Cohort Study",
  "title_text": "Prognostic Value of the Blood Urea Nitrogen-to-Fibrinogen Ratio for 30-Day Mortality in Patients with Severe Fever with Thrombocytopenia Syndrome: A Single-Center Retrospective Cohort Study",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T12:22:35Z",
  "url": "https://research.draconitic.com/paper/fbdfkfp8cc7py",
  "venue": "Infection and Drug Resistance",
  "versions": []
}