{
  "abstract": "Background: Semaglutide, a glucagon-like peptide-1 (GLP-1) receptor agonist, demonstrates significant anti-obesity and hypoglycemic effects in high-fat-diet (HFD)-induced obese models. However, both clinical and preclinical evidence indicates that semaglutide discontinuation inevitably leads to body weight rebound and progressive metabolic deterioration, severely compromising long-term therapeutic efficacy. Methods: To assess whether Lacticaseibacillus paracasei LP-18 alleviates post-semaglutide metabolic deterioration, we first confirmed its anti-obesity effect in HFD-fed mice, then used a three-stage model: HFD-induced obesity (4 weeks), semaglutide treatment (4 weeks), and withdrawal with or without L. paracasei LP-18 (4 weeks). Results:L. paracasei LP-18 supplementation effectively prevented post-discontinuation weight rebound and reduced cumulative energy intake while maintaining glucose homeostasis through decreased fasting and postprandial blood glucose levels. L. paracasei LP-18 also ameliorated dyslipidemia, reduced liver weight and hepatic lipid deposition, and attenuated white adipose tissue expansion and adipocyte hypertrophy. Mechanistically, L. paracasei LP-18 enriched beneficial taxa (Lacticaseibacillus, Bifidobacterium, Faecalibaculum) and depleted obesity-associated genera (Oribacterium, Anaerotruncus, Dorea), while restoring colonic barrier integrity via increased mucus layer thickness, goblet cell density, and upregulation of Muc2, ZO-1, and Occludin. Conclusions: These findings suggest that L. paracasei LP-18 is a promising probiotic strategy to alleviate post-semaglutide weight rebound and metabolic dysfunction, and its beneficial effects are associated with modulation of gut microbiota and preservation of intestinal barrier integrity.",
  "abstract_shown": true,
  "affiliations": [
    "Moon (Guangzhou) Biotech Co., Ltd., Huangpu District, Guangzhou 510530, China",
    "Department of Ocean Science and Engineering, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Wenjiao Cai"
    },
    {
      "affs": [
        0
      ],
      "name": "Ping Kong",
      "orcid": "0009-0004-1102-8663"
    },
    {
      "affs": [
        0
      ],
      "name": "Baojia Huang",
      "orcid": "0009-0004-5984-6569"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Wenbin Xue"
    },
    {
      "affs": [
        0
      ],
      "name": "Chenchen Zhang"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhou Lan"
    },
    {
      "affs": [
        0
      ],
      "name": "Amanda Juan Chen"
    },
    {
      "affs": [
        0
      ],
      "name": "Yibo Xian",
      "orcid": "0009-0002-3012-3741"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fbwry9tfs6v3f.bib",
  "cited_by": 0,
  "doi": "10.3390/metabo16110832",
  "fulltext_url": null,
  "id": "fbwry9tfs6v3f",
  "issns": [
    "2218-1989"
  ],
  "landing_url": "https://www.mdpi.com/2218-1989/16/11/832",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [],
  "openalex": null,
  "pdf_url": null,
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "MDPI AG",
  "ris": "https://research.draconitic.com/paper/fbwry9tfs6v3f.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:55Z",
      "native_id": "10.3390/metabo16110832",
      "source": "crossref",
      "url": "https://www.mdpi.com/2218-1989/16/11/832"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "issn:2218-1989",
      "subfield": "proteomics-metabolomics"
    }
  ],
  "title": "Lacticaseibacillus paracasei LP-18 Alleviates Post-Semaglutide Weight Rebound and Metabolic Dysfunction in Obese Mice",
  "title_text": "Lacticaseibacillus paracasei LP-18 Alleviates Post-Semaglutide Weight Rebound and Metabolic Dysfunction in Obese Mice",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T00:20:53Z",
  "url": "https://research.draconitic.com/paper/fbwry9tfs6v3f",
  "venue": "Metabolites",
  "versions": []
}