{
  "abstract": "Background: Preeclampsia (PE) is a hypertensive pregnancy disorder with contributions from both maternal and fetal genetic factors, but how both genomes regulate placental transcription remains incompletely understood. Results: We analyzed placental 5'-end RNA sequencing data from 59 pregnancies in the FINNPEC cohort and performed separate maternal and fetal cis-eQTL analyses using gene-level expression and promoter-level expression defined as Transcript Far 5' Ends (TFE). Genotype-by-PE interaction models were used to identify genetic effects that differ according to PE status. No gene-level interaction eQTLs remained significant after multiple-testing correction, although suggestive signals included LILRB2 in the maternal and LPCAT3 in the fetal analyses. In contrast, we identified two significant syntenic promoter-level interaction eQTLs: rs12504642-TFE61820 at the FHDC1 locus in the maternal analysis and rs1557150-TFE9032 at the PPIAP31 locus in the fetal analysis. Conclusion: These findings suggest that PE-dependent genetic interaction effects may be detectable at specific transcript promoter regions even when they are not captured at annotated gene levels.",
  "abstract_shown": true,
  "affiliations": [
    "University of Helsinki"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 12,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "G. Yazgeldi Gunaydin"
    },
    {
      "name": "J. Leinonen"
    },
    {
      "name": "S. Ezer"
    },
    {
      "name": "E. Kajantie"
    },
    {
      "name": "K. Kivinen"
    },
    {
      "name": "S. Heinonen"
    },
    {
      "name": "A. Pouta"
    },
    {
      "name": "FINNPEC Group"
    },
    {
      "name": "H. Laivuori"
    },
    {
      "name": "S. Wedenoja"
    },
    {
      "name": "J. Kere"
    },
    {
      "name": "S. Katayama"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fc82j0k994f44.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.05.756656",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756656v1.full",
  "id": "fc82j0k994f44",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756656v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "genetics"
    ],
    [
      "openalex",
      "2729|Pregnancy and preeclampsia studies"
    ]
  ],
  "openalex": "W7220830403",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756656v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fc82j0k994f44.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:26:28Z",
      "native_id": "10.64898/2026.10.05.756656",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.05.756656v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:genetics",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Placental cis-eQTL analysis identifies preeclampsia-dependent genetic regulation at promoters",
  "title_text": "Placental cis-eQTL analysis identifies preeclampsia-dependent genetic regulation at promoters",
  "type": "preprint",
  "updated_at": "2026-10-30T12:26:28Z",
  "url": "https://research.draconitic.com/paper/fc82j0k994f44",
  "venue": "bioRxiv",
  "versions": []
}