{
  "abstract": "Rationale:: Immune-mediated necrotizing myopathy (IMNM) is a rare inflammatory myopathy. Coexisting anti-signal recognition particle (anti-SRP) and anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (anti-HMGCR) antibodies in statin-naïve patients with interstitial lung disease are exceptionally uncommon.\n\nPatient concerns:: A 55-year-old statin-naïve man presented with progressive proximal muscle weakness, dysphagia, myalgia, significant weight loss, and exertional dyspnea.\n\nDiagnoses:: Serum creatine kinase was 8000 U/L. Anti-SRP, anti-HMGCR, and anti-Ro52 antibodies were positive. Chest computed tomography showed bilateral consolidations and ground-glass opacities suggestive of organizing pneumonia. Pulmonary function tests revealed reduced forced vital capacity (52%) and diffusing capacity for carbon monoxide (48%). Electromyography and muscle biopsy findings supported IMNM.\n\nInterventions:: Treatment included high-dose corticosteroids, mycophenolate mofetil, nutritional support, and rehabilitation.\n\nOutcomes:: After 3 months, muscle strength improved from 3/5 to 4+/5, dysphagia resolved, and weight increased by 5 kg. Creatine kinase decreased to 350 U/L, forced vital capacity improved to 74%, and diffusing capacity for carbon monoxide to 65%. Follow-up high-resolution computed tomography showed pulmonary improvement without fibrosis.\n\nLessons:: This case highlights the rare coexistence of anti-SRP and anti-HMGCR antibodies in statin-naïve IMNM with interstitial lung disease. Early immunosuppression, nutritional support, and rehabilitation may improve muscular and pulmonary outcomes. Comprehensive respiratory assessment and longitudinal monitoring are essential.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Pulmonology, Shifa International Hospital, Islamabad, Pakistan",
    "Department of Medicine, Shifa College of Medicine, Islamabad, Pakistan",
    "Department of Medicine, Services Institute of Medical Sciences, Lahore, Pakistan",
    "Department of Medicine, Women Medical and Dental College, Abbottabad, Pakistan",
    "Department of Medicine, Nasrat Bashir Curative Hospital, Kandahar, Afghanistan."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 5,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Muhammad Imran"
    },
    {
      "affs": [
        1
      ],
      "name": "Muhammad Hassaan Javaid"
    },
    {
      "affs": [
        2
      ],
      "name": "Zohad Fareh"
    },
    {
      "affs": [
        3
      ],
      "name": "Maryam Alam Wazir"
    },
    {
      "affs": [
        4
      ],
      "name": "Kamil Ahmad Kamil",
      "orcid": "0009-0000-8208-0689"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fccr270yxseh1.bib",
  "cited_by": 0,
  "doi": "10.1097/md.0000000000051232",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727274/?tool=EBI",
  "id": "fccr270yxseh1",
  "issns": [
    "0304-5412",
    "1536-5964",
    "0025-7974"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13727274",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "6900"
    ],
    [
      "heading",
      "Clinical Case Report"
    ],
    [
      "heading",
      "Research Article"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13727274/pdf/?tool=EBI",
  "pmcid": "PMC13727274",
  "pmid": null,
  "published": "2026-10-30",
  "publisher": "Wolters Kluwer Health",
  "ris": "https://research.draconitic.com/paper/fccr270yxseh1.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:51Z",
      "native_id": "PMC:PMC13727274",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13727274"
    },
    {
      "first_seen": "2026-11-05T12:23:23Z",
      "native_id": "PMC13727274",
      "source": "pmc",
      "url": "https://doi.org/10.1097/md.0000000000051232"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "journal-openalex:F27",
      "subfield": "general"
    }
  ],
  "title": "Anti-SRP and anti-HMGCR co-positivity in immune-mediated necrotizing myopathy with interstitial lung disease : A rare case report",
  "title_text": "Anti-SRP and anti-HMGCR co-positivity in immune-mediated necrotizing myopathy with interstitial lung disease : A rare case report",
  "type": "peer-reviewed",
  "updated_at": "2026-11-06T12:22:59Z",
  "url": "https://research.draconitic.com/paper/fccr270yxseh1",
  "venue": "Medicine",
  "versions": []
}