{
  "abstract": "Emerging evidence has shown that microbiota dysbiosis and aberrant bile acid (BA) profiles correlates with disease progression. However, it’s role in psoriasis progression remains unclear. This study elucidates dysregulated BA metabolism in psoriasis patients and imiquimod-treated mice, coupled with increased expression of the farnesoid X receptor (FXR) in keratinocyte. FXR activation with glycochenodeoxycholic acid (GCDCA) ameliorates psoriatic symptoms by enhancing lipid metabolism, particularly fatty acid oxidation. Mechanistically, the FXR-mediated enhancement of antioxidant capacity by upregulating NAD(P)H quinone dehydrogenase 1 (NQO1) expression underlies its regulatory role in lipid metabolism, offering a new insight into FXR’s role in oxidation stress and lipid metabolism. Conversely, keratinocyte-specific FXR ablation exacerbates psoriasis severity. Gut microbiota dysbiosis is further identified as a pivotal contributor to perturbed the profile of BA in psoriasis. These findings establish the gut microbiota-BA-FXR axis as a critical pathway in psoriasis pathogenesis and suggest probiotics/prebiotics as viable therapeutic interventions.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Dermatology, The First Affiliated Hospital, Key Laboratory of Dermatology, Ministry of Education, Anhui Medical University, Hefei, P. R. China",
    "State Key Laboratory of Pharmaceutical Biotechnology, State Key Laboratory of Analytical Chemistry for Life Science, Affiliated Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, P. R. China",
    "Department of Dermatology, First Affiliated Hospital, Nanjing Medical University, Nanjing, P. R. China",
    "Suqian Scientific Research Institute of Nanjing University Medical School, Suqian, P. R. China",
    "Technique Center, Jinling Pharmaceutical Company Limited, Nanjing, P. R. China",
    "Centre for Computational Biology, Duke-NUS Medical School, Outram, Singapore",
    "Department of Medicine Huddinge, Unit for Gastroenterology and Nutrition, Karolinska Institute, Huddinge, Sweden",
    "Research Center for High Altitude Medicine, Laboratory for High Altitude Medicine of Qinghai Province, Qinghai University, Xining, P. R. China",
    "Department of Dermatology, First Affiliated Hospital, Nanjing Medical University, Nanjing, P. R. China. suzhonglan@jsph.org.cn",
    "State Key Laboratory of Pharmaceutical Biotechnology, State Key Laboratory of Analytical Chemistry for Life Science, Affiliated Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, P. R. China. hwang@nju.edu.cn",
    "State Key Laboratory of Pharmaceutical Biotechnology, State Key Laboratory of Analytical Chemistry for Life Science, Affiliated Nanjing Drum Tower Hospital, Medical School, Nanjing University, Nanjing, P. R. China. zhiqiang.huang@nju.edu.cn"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 16,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Panpan Lian"
    },
    {
      "affs": [
        1
      ],
      "name": "Renwei Lu"
    },
    {
      "affs": [
        1
      ],
      "name": "Chaode Gu"
    },
    {
      "affs": [
        1
      ],
      "name": "Junaid Wazir",
      "orcid": "0000-0001-9299-4716"
    },
    {
      "affs": [
        2
      ],
      "name": "Wentong Wang",
      "orcid": "0000-0002-1040-3378"
    },
    {
      "affs": [
        2
      ],
      "name": "Yangyongyi Zong"
    },
    {
      "affs": [
        3
      ],
      "name": "Yun Xia"
    },
    {
      "affs": [
        4
      ],
      "name": "Jie Ni"
    },
    {
      "affs": [
        5
      ],
      "name": "Huimei Chen",
      "orcid": "0000-0001-7788-1334"
    },
    {
      "affs": [
        5
      ],
      "name": "Enrico G. Petretto",
      "orcid": "0000-0003-2163-5921"
    },
    {
      "affs": [
        6
      ],
      "name": "Eckardt Treuter",
      "orcid": "0000-0002-4147-8989"
    },
    {
      "affs": [
        6
      ],
      "name": "Rongrong Fan",
      "orcid": "0000-0002-5707-1497"
    },
    {
      "affs": [
        7
      ],
      "name": "Airong Yang"
    },
    {
      "affs": [
        8
      ],
      "name": "Zhonglan Su",
      "orcid": "0000-0001-6055-2104"
    },
    {
      "affs": [
        9
      ],
      "name": "Hongwei Wang",
      "orcid": "0000-0003-2868-5112"
    },
    {
      "affs": [
        10
      ],
      "name": "Zhiqiang Huang",
      "orcid": "0000-0001-5208-008X"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fck3fe1vrq8w1.bib",
  "cited_by": 5,
  "doi": "10.1038/s41467-026-72417-5",
  "fulltext_url": null,
  "id": "fck3fe1vrq8w1",
  "issns": [
    "2041-1723"
  ],
  "landing_url": "https://doi.org/10.1038/s41467-026-72417-5",
  "language": "en",
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "2403|Psoriasis: Treatment and Pathogenesis"
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  "openalex": "W7161563852",
  "pdf_url": null,
  "pmcid": "PMC13381536",
  "pmid": "42151128",
  "published": "2026-05-18",
  "publisher": "Nature Portfolio",
  "ris": "https://research.draconitic.com/paper/fck3fe1vrq8w1.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T13:26:51Z",
      "native_id": "W7161563852",
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      "url": "https://doi.org/10.1038/s41467-026-72417-5"
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  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:2403|Psoriasis: Treatment and Pathogenesis",
      "subfield": "immunology"
    }
  ],
  "title": "Gut microbiota-induced perturbation in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis",
  "title_text": "Gut microbiota-induced perturbation in bile acids alter keratinocyte lipid metabolism via FXR-NQO1 signaling in psoriasis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-07T13:20:53Z",
  "url": "https://research.draconitic.com/paper/fck3fe1vrq8w1",
  "venue": "Nature Communications",
  "versions": []
}