{
  "abstract": "Hedysarum polysaccharide (HPS), the major bioactive constituent of Radix Hedysari, possesses anti-inflammatory activity; however, few studies have explored its application for ulcerative colitis (UC). In this study, HPS-80 was extracted using combined complex-enzyme hydrolysis and ultrasonication. We further evaluated its preventive effects and underlying mechanisms in a dextran sulfate sodium (DSS)-induced UC model in C57BL/6 mice. Results showed HPS-80 significantly improved DSS-induced UC symptoms (weight loss, hematochezia, colon shortening) and reduced Disease Activity Index (DAI). Mechanistically, it inhibited pro-inflammatory factors Tumor Necrosis Factor-alpha(TNF-α),Interleukin-6, (IL-6), alleviated oxidative stress, upregulated tight junction proteins occludin, claudin-1(ZO-1), and modulated intestinal microbiota (suppressed harmful bacteria like Bacteroidota, enriched beneficial ones like Firmicutes and Akkermansia). Conclusion: HPS-80 exerts protective effects against UC via anti-inflammatory, antioxidant and gut-microbiota-regulating capacities. It is a promising candidate agent for UC prevention.",
  "abstract_shown": true,
  "affiliations": [
    "Key Laboratory of Structure-Specific Small Molecule Drugs at Chengdu Medical College of Sichuan Province, School of Pharmacy, Chengdu Medical College , ,"
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Lujie Ma"
    },
    {
      "affs": [
        0
      ],
      "name": "Yu Han"
    },
    {
      "affs": [
        0
      ],
      "name": "Xueqin Zhao"
    },
    {
      "affs": [
        0
      ],
      "name": "Yixiu Niu"
    },
    {
      "affs": [
        0
      ],
      "name": "Yuxin Xie"
    },
    {
      "affs": [
        0
      ],
      "name": "Yating Pan"
    },
    {
      "affs": [
        0
      ],
      "name": "Yaxin Zheng"
    },
    {
      "affs": [
        0
      ],
      "name": "Zhiyuan Xue"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fcmafr2qqr4zx.bib",
  "cited_by": 0,
  "doi": "10.3389/fimmu.2026.1944924",
  "fulltext_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673562/?tool=EBI",
  "id": "fcmafr2qqr4zx",
  "issns": [
    "1664-3224"
  ],
  "landing_url": "https://europepmc.org/article/PMC/PMC13673562",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1311|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W7215969497",
  "pdf_url": "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13673562/pdf/?tool=EBI",
  "pmcid": "PMC13673562",
  "pmid": null,
  "published": "2026-10-02",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/fcmafr2qqr4zx.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:18:18Z",
      "native_id": "PMC:PMC13673562",
      "source": "europepmc",
      "url": "https://europepmc.org/article/PMC/PMC13673562"
    },
    {
      "first_seen": "2026-10-30T12:19:15Z",
      "native_id": "10.3389/fimmu.2026.1944924",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fimmu.2026.1944924/full"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Inflammatory Bowel Disease",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Polysaccharides from Radix Hedysari exhibited preventive effects against DSS-induced ulcerative colitis in C57BL/6 mice",
  "title_text": "Polysaccharides from Radix Hedysari exhibited preventive effects against DSS-induced ulcerative colitis in C57BL/6 mice",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:19:15Z",
  "url": "https://research.draconitic.com/paper/fcmafr2qqr4zx",
  "venue": "Frontiers in immunology",
  "versions": []
}