{
  "abstract": "Here we introduce TurboANI, a fast homology-aware average nucleotide identity (ANI) estimation algorithm that implements the seed-chain-quasi-alignment scheme using SIMD seeding, compact indexing, lightweight chaining, and cache-friendly bitset sliding minwise hashing, achieving up to ~40,000-fold speedup over the alignment-based ANI algorithm with near-perfect agreement. TurboANI is also >40-fold faster than the state-of-the-art FastANI and ten-fold faster than skani while maintaining better accuracy. In the sensitive mode, it has a ten-fold higher true-ANI recovery rate than skani.",
  "abstract_shown": true,
  "affiliations": [
    "University of California San Diego"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "J. Zhao"
    },
    {
      "name": "D. McDonald"
    },
    {
      "name": "L. Patel"
    },
    {
      "name": "C. Wang"
    },
    {
      "name": "A. Gonzalez"
    },
    {
      "affs": [
        0
      ],
      "name": "R. Knight"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fcmjac00679sy.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.11.05.764740",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.11.05.764740v1.full",
  "id": "fcmjac00679sy",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.11.05.764740v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "bioinformatics"
    ]
  ],
  "openalex": null,
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.11.05.764740v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-11-05",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fcmjac00679sy.ris",
  "sources": [
    {
      "first_seen": "2026-11-09T12:21:46Z",
      "native_id": "10.64898/2026.11.05.764740",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.11.05.764740v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:bioinformatics",
      "subfield": "bioinformatics"
    }
  ],
  "title": "Homology-aware average nucleotide identity estimation at scale with TurboANI",
  "title_text": "Homology-aware average nucleotide identity estimation at scale with TurboANI",
  "type": "preprint",
  "updated_at": "2026-11-10T00:23:15Z",
  "url": "https://research.draconitic.com/paper/fcmjac00679sy",
  "venue": "bioRxiv",
  "versions": []
}