{
  "abstract": "Background/Objectives: The present study evaluated the early clinical outcomes and translational proof-of-concept of a simplified guided single-implant workflow for mandibular overdenture rehabilitation in edentulous patients. Methods: A prospective translational clinical pilot study was conducted in 15 edentulous patients treated using a simplified flapless guided single-implant mandibular overdenture protocol. The workflow was designed to reduce procedural complexity while maintaining clinically applicable surgical and prosthetic integration under routine treatment conditions. All surgical procedures were performed by a single experienced operator. The study was conducted following institutional ethical approval and informed consent procedures. Clinical, radiographic, peri-implant, prosthetic, and patient-reported outcomes were evaluated during the 1-year follow-up period. Marginal bone loss, peri-implant clinical parameters, complications, implant survival, and Oral Health Impact Profile (OHIP-14) scores were assessed. Results: All planned surgical and prosthetic procedures were completed successfully, with no major intraoperative or protocol-related complications. Implant survival was 100% during the 1-year follow-up period. Mean marginal bone loss was 0.19 ± 0.21 mm at loading and 0.25 ± 0.28 mm at 1 year. Peri-implant clinical parameters remained favorable throughout follow-up. Significant improvement in patient-reported quality-of-life outcomes was observed, with OHIP-14 scores demonstrating substantial reduction following treatment (p < 0.001). The simplified guided approach demonstrated favorable translational feasibility and practical clinical integration under routine treatment conditions. Conclusions: Within the limitations of this prospective translational clinical proof-of-concept study, the proposed simplified guided single-implant workflow demonstrated encouraging early clinical, radiographic, and patient-centered outcomes for mandibular overdenture rehabilitation. Further multicenter investigations involving larger patient cohorts, multiple operators, longer follow-up periods, and comparative study designs are required to evaluate long-term clinical performance, reproducibility, and comparative effectiveness relative to established treatment protocols.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Periodontology, Dental School, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium.",
    "Cosmident, Private Practice, 2500 Lier, Belgium.",
    "Department of Reconstructive Dentistry, Dental School, Faculty of Medicine and Health Sciences, Ghent University, 9000 Ghent, Belgium."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 4,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Marco Tudts",
      "orcid": "0009-0006-1843-1839"
    },
    {
      "affs": [
        1
      ],
      "name": "Tashia Moodley"
    },
    {
      "affs": [
        2
      ],
      "name": "Rani D'haese",
      "orcid": "0000-0002-6194-0931"
    },
    {
      "affs": [
        2
      ],
      "name": "Stefan Vandeweghe"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fda4p055dz2ex.bib",
  "cited_by": 0,
  "doi": "10.3390/dj14100654",
  "fulltext_url": "https://europepmc.org/articles/PMC13703345",
  "id": "fda4p055dz2ex",
  "issns": [
    "2304-6767"
  ],
  "landing_url": "https://europepmc.org/article/MED/42930420",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "3504|Dental Implant Techniques and Outcomes"
    ]
  ],
  "openalex": "W7221106175",
  "pdf_url": "https://europepmc.org/articles/PMC13703345?pdf=render",
  "pmcid": "PMC13703345",
  "pmid": "42930420",
  "published": "2026-10-09",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fda4p055dz2ex.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:22:01Z",
      "native_id": "MED:42930420",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42930420"
    }
  ],
  "subjects": [],
  "title": "Early Clinical Outcomes of a Simplified Guided Single-Implant Workflow for Mandibular Overdentures: A Prospective Translational Proof-of-Concept Study.",
  "title_text": "Early Clinical Outcomes of a Simplified Guided Single-Implant Workflow for Mandibular Overdentures: A Prospective Translational Proof-of-Concept Study.",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:22:01Z",
  "url": "https://research.draconitic.com/paper/fda4p055dz2ex",
  "venue": "Dentistry journal",
  "versions": []
}