{ "abstract": "Background/Objectives: The apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio has been proposed as an integrated marker of atherogenic and anti-atherogenic lipoprotein balance. This study assessed its association with the presence and angiographic severity of coronary artery disease (CAD) and compared its discriminatory performance with conventional lipid markers. Methods: This retrospective, observational, cross-sectional study included 63 adults undergoing coronary angiography for suspected or established CAD. Pre-procedural ApoB, ApoA1, and conventional lipid parameters were measured. Significant CAD was defined as ≥50% stenosis in at least one major epicardial coronary artery. Associations with angiographic severity were assessed using Gensini and SYNTAX scores. Statistical analyses included between-group comparisons, Spearman correlations, ROC analysis with DeLong comparisons, and logistic regression. Results: Significant CAD was present in 46 patients (73.02%). ApoB and ApoB/ApoA1 were higher in patients with significant CAD (p = 0.011 and p = 0.013), whereas ApoA1 was not (p = 0.101). ApoB/ApoA1 correlated weakly with Gensini score (ρ = 0.30, p = 0.046), but not with SYNTAX Scores I or II. In the complete-case subset (n = 55), ApoB/ApoA1 had an AUC of 0.68, with no significant differences versus LDL-C, HDL-C, total cholesterol, or triglycerides. Each 0.1-unit increase in ApoB/ApoA1 was associated with higher odds of significant CAD after adjustment for age, diabetes mellitus, and smoking (adjusted OR 1.63, 95% CI 1.08-2.48; p = 0.021). Conclusions: ApoB/ApoA1 was associated with significant CAD after adjustment for selected clinical variables, but this association was attenuated after additional adjustment for LDL-C. Its discriminatory performance was modest and not significantly different from conventional lipid markers, requiring further evaluation as a potential pre-angiographic risk marker.", "abstract_shown": true, "affiliations": [ "Medical Semiology II Discipline, Department V-Internal Medicine I, Faculty of Medicine, \"Victor Babeș\" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.", "Multidisciplinary Heart Research Center, Faculty of Medicine, \"Victor Babeș\" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.", "Cardiology Clinic-ASCAR, Timișoara Municipal Emergency Clinical Hospital, Bd. Revoluției din 1989 No. 12, 300041 Timișoara, Romania.", "Medical Semiology I Discipline, Department V-Internal Medicine I, Faculty of Medicine, \"Victor Babeș\" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.", "ANAPATMOL Research Center, \"Victor Babeș\" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.", "Department of Oncology, ONCOHELP Hospital, Ciprian Porumbescu Street No. 59, 300239 Timișoara, Romania.", "Faculty of Medicine, \"Victor Babeș\" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.", "Department of Family Medicine, Centre for Preventive Medicine, \"Victor Babeș\" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.", "Department of Biology-Chemistry, Faculty of Chemistry, Biology, Geography, West University of Timișoara, Johann Heinrich Pestalozzi Street No. 16A, 300115 Timișoara, Romania.", "Department of Microbiology, \"Victor Babeș\" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.", "Multidisciplinary Research Center on Antimicrobial Resistance (MULTI-REZ), Department of Microbiology, \"Victor Babeș\" University of Medicine and Pharmacy, Eftimie Murgu Square No. 2, 300041 Timișoara, Romania.", "Clinical Laboratory, \"Louis Țurcanu\" Emergency Clinical Hospital for Children, Iosif Nemoianu Street No. 2, 300011 Timișoara, Romania.", "Department of Allergology, Giroc Medical Center, Str. Trandafirilor No. 7, 307220 Timiș, Romania." ], "article_type": "research article", "arxiv": null, "author_total": 12, "authors": [ { "affs": [ 0, 1 ], "name": "Tiberiu-Liviu Dragomir" }, { "affs": [ 0, 1, 2 ], "name": "Horia Silviu Branea", "orcid": "0000-0002-7896-1253" }, { "affs": [ 0, 1, 2 ], "name": "Minodora Andor" }, { "affs": [ 1, 2, 3 ], "name": "Ioana Mihaela Cîtu", "orcid": "0000-0001-8728-5413" }, { "affs": [ 0, 1, 2 ], "name": "Florina Rozina Căruntu" }, { "affs": [ 3 ], "name": "Monica Maria Șușan" }, { "affs": [ 4, 5 ], "name": "Cristina Marinela Oprean", "orcid": "0000-0001-5000-5422" }, { "affs": [ 6 ], "name": "Raul-Tiberiu Dragomir" }, { "affs": [ 7 ], "name": "Răzvan Mihai Șușan", "orcid": "0000-0003-3531-3974" }, { "affs": [ 8 ], "name": "Delia Huțanu", "orcid": "0000-0002-1335-6845" }, { "affs": [ 9, 10, 11 ], "name": "Dan Dumitru Vulcanescu", "orcid": "0000-0003-1046-7272" }, { "affs": [ 12 ], "name": "Adriana Daniela Dragomir" } ], "bibtex": "https://research.draconitic.com/paper/fdbrdpk2yap1v.bib", "cited_by": 0, "doi": "10.3390/diagnostics16193245", "fulltext_url": "https://europepmc.org/articles/PMC13664346", "id": "fdbrdpk2yap1v", "issns": [ "2075-4418" ], "landing_url": "https://europepmc.org/article/MED/42882400", "language": "eng", "licence": "CC-BY", "licence_label": "CC BY", "licence_source": "article", "licence_url": "https://creativecommons.org/licenses/by/4.0/", "metadata_licence": null, "native_subjects": [ [ "openalex", "2746|Lipoproteins and Cardiovascular Health" ] ], "openalex": "W7220918610", "pdf_url": "https://europepmc.org/articles/PMC13664346?pdf=render", "pmcid": "PMC13664346", "pmid": "42882400", "published": "2026-10-08", "publisher": null, "ris": "https://research.draconitic.com/paper/fdbrdpk2yap1v.ris", "sources": [ { "first_seen": "2026-10-30T12:19:00Z", "native_id": "MED:42882400", "source": "europepmc", "url": "https://europepmc.org/article/MED/42882400" } ], "subjects": [ { "field": "medicine", "origin": "openalex:2746|Lipoproteins and Cardiovascular Health", "subfield": "surgery" } ], "title": "Association of the ApoB/ApoA1 Ratio with Angiographically Documented Coronary Artery Disease: Comparison with Conventional Lipid Markers.", "title_text": "Association of the ApoB/ApoA1 Ratio with Angiographically Documented Coronary Artery Disease: Comparison with Conventional Lipid Markers.", "type": "peer-reviewed", "updated_at": "2026-10-30T12:19:00Z", "url": "https://research.draconitic.com/paper/fdbrdpk2yap1v", "venue": "Diagnostics (Basel, Switzerland)", "versions": [] }