{
  "abstract": "Camellia sinensis (green tea) contains bioactive polyphenols with potential antiangiogenic activity; however, its therapeutic application is limited by extract complexity and challenges related to delivery. This study developed a lipid-polymeric nanoparticle system containing a chemically standardized C. sinensis extract and evaluated its physicochemical properties, biocompatibility, and antiangiogenic activity. The optimized nanoformulation exhibited a mean diameter of 202.0 ± 5.2 nm, polydispersity index (PDI) of 0.156 ± 0.017, and zeta potential of -25.1 ± 0.6 mV, with an encapsulation efficiency of approximately 34.6 ± 1.5%. The formulation maintained suitable physicochemical characteristics during storage and showed no relevant irritation in the HET-CAM assay. In the chick chorioallantoic membrane (CAM) assay, extract-loaded nanoparticles reduced vascularization, displaying an antiangiogenic effect comparable to bevacizumab. These findings support lipid-polymeric nanoencapsulation as a promising strategy to improve the biological performance of complex plant-derived extracts for ocular angiogenic disorders.",
  "abstract_shown": true,
  "affiliations": [
    "Serviço De Desenvolvimento Tecnológico Farmacêutico, Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil.",
    "Serviço De Toxinologia Molecular, Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil.",
    "Serviço De Ecotoxinologia, Diretoria de Pesquisa e Desenvolvimento, Fundação Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil.",
    "Serviço Química Especializada, Diretoria Do Instituto Octávio Magalhães, Fundação Ezequiel Dias, Belo Horizonte, Minas Gerais, Brazil."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Sarah Kelly Fernandes",
      "orcid": "0009-0006-3935-3753"
    },
    {
      "affs": [
        0
      ],
      "name": "Anízio Bastos de Souza"
    },
    {
      "affs": [
        0
      ],
      "name": "Líbia Andressa Leandro de Paula",
      "orcid": "0009-0000-6643-5187"
    },
    {
      "affs": [
        1
      ],
      "name": "Alessandra Cristine de Souza Matavel"
    },
    {
      "affs": [
        2
      ],
      "name": "Marcos Paulo Gomes Mol",
      "orcid": "0000-0002-2568-3579"
    },
    {
      "affs": [
        3
      ],
      "name": "Mariana de Oliveira Almeida"
    },
    {
      "affs": [
        3
      ],
      "name": "Vanessa Heloísa Ferreira de Faria"
    },
    {
      "affs": [
        0
      ],
      "name": "Carolina Paula de Souza Moreira",
      "orcid": "0000-0001-9985-6252"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fdgkbtavrnd0m.bib",
  "cited_by": 0,
  "doi": "10.1002/cbdv.71893",
  "fulltext_url": "https://europepmc.org/articles/PMC13724159",
  "id": "fdgkbtavrnd0m",
  "issns": [
    "1612-1872",
    "1612-1880"
  ],
  "landing_url": "https://europepmc.org/article/MED/42967485",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Research Article"
    ],
    [
      "openalex",
      "3003|Advanced Drug Delivery Systems"
    ]
  ],
  "openalex": "W7225045373",
  "pdf_url": "https://europepmc.org/articles/PMC13724159?pdf=render",
  "pmcid": "PMC13724159",
  "pmid": "42967485",
  "published": "2026-11-01",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fdgkbtavrnd0m.ris",
  "sources": [
    {
      "first_seen": "2026-11-03T15:20:53Z",
      "native_id": "MED:42967485",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42967485"
    },
    {
      "first_seen": "2026-11-04T12:22:40Z",
      "native_id": "PMC13724159",
      "source": "pmc",
      "url": "https://doi.org/10.1002/cbdv.71893"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:3003|Advanced Drug Delivery Systems",
      "subfield": "pharmacology-toxicology"
    }
  ],
  "title": "Lipid-Polymeric Nanoencapsulation of Standardized Camellia sinensis Extract Enhances Antiangiogenic Activity and Ocular Biocompatibility.",
  "title_text": "Lipid-Polymeric Nanoencapsulation of Standardized Camellia sinensis Extract Enhances Antiangiogenic Activity and Ocular Biocompatibility.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-05T12:20:51Z",
  "url": "https://research.draconitic.com/paper/fdgkbtavrnd0m",
  "venue": "Chemistry & biodiversity",
  "versions": []
}