{
  "abstract": "Introduction: Triple-negative breast cancer (TNBC) is a highly aggressive and heterogeneous subtype of breast cancer associated with poor prognosis, limited therapeutic options, and high recurrence rates.\n\nMethods: In this study, we evaluated the therapeutic potential of an AptaBreast panel (AB-panel) previously identified for its ability to recognize TNBC cells specifically. Functional assays were performed in various TNBC cell lines representing distinct intrinsic subtypes, as well as in non-tumoral cells (MCF10A).\n\nResults: Functional assays revealed that the aptamers effectively reduced tumor cell viability, proliferation, migration and colony formation in various TNBC cell lines. Importantly, the combined treatment with all five aptamers resulted in an enhanced overall antitumor effect. Notably, the aptamers demonstrated selective action on tumor cells without significant cytotoxicity to non-tumoral cells (MCF10A).\n\nDiscussion: The observed effects support the potential of these aptamers as therapeutic candidates for TNBC and warrant further investigation into their molecular targets and mechanisms of action. Collectively, our findings highlight their potential across different TNBC cellular models, while further studies are needed to assess their therapeutic efficacy, safety, and applicability in more complex models. These results provide a basis for future preclinical studies aimed at further evaluating their potential in TNBC.",
  "abstract_shown": true,
  "affiliations": [
    "Laboratory of Applied Genomics and Bioinnovations, Oswaldo Cruz Institute, Fiocruz",
    "Laboratory of Clinical and Experimental Pathophysiology, Oswaldo Cruz Institute, Fiocruz",
    "Translational Oncology Platform, Center for Technological Development in Health, Fiocruz"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Natassia Silva de Araujo"
    },
    {
      "affs": [
        0
      ],
      "name": "Aline dos Santos Moreira"
    },
    {
      "affs": [
        0
      ],
      "name": "Rayane da Silva Abreu"
    },
    {
      "affs": [
        0
      ],
      "name": "Julia Badaró Mendonça"
    },
    {
      "affs": [
        0
      ],
      "name": "Tayanne Felippe Sassaro"
    },
    {
      "affs": [
        0
      ],
      "name": "Wim Degrave"
    },
    {
      "affs": [
        1,
        2
      ],
      "name": "Tatiana Martins Tilli"
    },
    {
      "affs": [
        0
      ],
      "name": "Mariana Caldas Waghabi"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fdkmee8hpx2tf.bib",
  "cited_by": 0,
  "doi": "10.3389/fonc.2026.1943528",
  "fulltext_url": null,
  "id": "fdkmee8hpx2tf",
  "issns": [
    "2234-943X"
  ],
  "landing_url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1943528/full",
  "language": null,
  "licence": "CC-BY-4.0",
  "licence_label": "CC BY 4.0",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1312|Advanced biosensing and bioanalysis techniques"
    ]
  ],
  "openalex": "W7223118224",
  "pdf_url": "https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1943528/pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-21",
  "publisher": "Frontiers Media SA",
  "ris": "https://research.draconitic.com/paper/fdkmee8hpx2tf.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:20:13Z",
      "native_id": "10.3389/fonc.2026.1943528",
      "source": "crossref",
      "url": "https://www.frontiersin.org/articles/10.3389/fonc.2026.1943528/full"
    }
  ],
  "subjects": [
    {
      "field": "biochemistry",
      "origin": "openalex:1312|Advanced biosensing and bioanalysis techniques",
      "subfield": "molecular-biology"
    }
  ],
  "title": "Novel aptamer-based strategies for addressing aggressive and heterogeneous triple-negative breast cancer",
  "title_text": "Novel aptamer-based strategies for addressing aggressive and heterogeneous triple-negative breast cancer",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:20:13Z",
  "url": "https://research.draconitic.com/paper/fdkmee8hpx2tf",
  "venue": "Frontiers in Oncology",
  "versions": []
}