{
  "abstract": ", inhibition of the METTL1/m7G/SLC7A11 axis exacerbates chronic DSS-induced colitis but alleviates acute DSS-induced colitis, revealing a switch from adaptive to maladaptive signaling with escalating metabolic stress. Collectively, these findings establish the METTL1-m7G-SLC7A11 axis as a metabolic rheostat that integrates inflammatory cues and nutrient availability to determine epithelial cell fate in UC, highlighting the importance of stage- and context-specific therapeutic strategies.",
  "abstract_shown": true,
  "affiliations": [
    "Center for Clinical Sciences, Japan Institute for Health Security, Tokyo, Japan",
    "Department of General Surgery, The Second Xiangya Hospital of Central South University, 410011 Changsha, China"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 7,
  "authors": [
    {
      "affs": [
        0,
        1
      ],
      "name": "Lichao Yang",
      "orcid": "0000-0003-0674-3123"
    },
    {
      "affs": [
        1
      ],
      "name": "Qi Sun"
    },
    {
      "affs": [
        1
      ],
      "name": "Zhixian Jiang"
    },
    {
      "affs": [
        1
      ],
      "name": "Baojia Yao"
    },
    {
      "affs": [
        1
      ],
      "name": "Caimei Yang"
    },
    {
      "affs": [
        1
      ],
      "name": "Ganglei Liu"
    },
    {
      "affs": [
        1
      ],
      "name": "Lianwen Yuan",
      "orcid": "0000-0001-5089-5066"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fe4w7phc6b46q.bib",
  "cited_by": 6,
  "doi": "10.7150/ijbs.133562",
  "fulltext_url": null,
  "id": "fe4w7phc6b46q",
  "issns": [
    "1449-2288"
  ],
  "landing_url": "https://doi.org/10.7150/ijbs.133562",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "openalex",
      "1311|Inflammatory Bowel Disease"
    ]
  ],
  "openalex": "W7162520312",
  "pdf_url": null,
  "pmcid": "PMC13215248",
  "pmid": "42212324",
  "published": "2026-05-11",
  "publisher": "Ivyspring International Publisher",
  "ris": "https://research.draconitic.com/paper/fe4w7phc6b46q.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T13:20:45Z",
      "native_id": "W7162520312",
      "source": "openalex",
      "url": "https://doi.org/10.7150/ijbs.133562"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Inflammatory Bowel Disease",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "A context-dependent METTL1-m7G-SLC7A11 axis links metabolic stress to epithelial fate in ulcerative colitis",
  "title_text": "A context-dependent METTL1-m7G-SLC7A11 axis links metabolic stress to epithelial fate in ulcerative colitis",
  "type": "peer-reviewed",
  "updated_at": "2026-11-03T13:20:30Z",
  "url": "https://research.draconitic.com/paper/fe4w7phc6b46q",
  "venue": "International Journal of Biological Sciences",
  "versions": []
}