{
  "abstract": "OBJECTIVE: Pemafibrate extended-release (XR), a once-daily formulation of pemafibrate, was developed to improve treatment convenience. However, real-world evidence regarding its long-term effectiveness, particularly after switching from conventional twice-daily pemafibrate, is limited. This study evaluated the efficacy and safety of pemafibrate XR in patients with hypertriglyceridemia. PATIENTS OR MATERIALS: This retrospective observational study included 115 patients treated with pemafibrate XR for 12 months. Changes in the lipid profiles, liver-related biochemical parameters, and metabolic parameters were evaluated. A subgroup analysis was performed in patients who switched from conventional twice-daily pemafibrate to pemafibrate XR. RESULTS: The triglyceride levels significantly decreased from 226 [142.5-368] mg/dL at baseline to 148 [112-203.5] mg/dL at 12 months (p<0.001). The high-density lipoprotein cholesterol levels significantly increased, whereas the low-density lipoprotein cholesterol levels remained unchanged. Liver-related parameters, including alanine aminotransferase, γ-glutamyl transpeptidase, and alkaline phosphatase, significantly improved, whereas the Fibrosis-4 index did not. The serum albumin levels increased, whereas the uric acid levels decreased after treatment. In the switch subgroup (n=75), the triglyceride and alanine aminotransferase levels significantly improved after the switch. CONCLUSION: Pemafibrate XR was associated with improvements in the triglyceride levels and liver-related biochemical parameters in real-world clinical practice. Among patients switched from twice-daily pemafibrate, favorable lipid and liver-related biochemical parameters were maintained during treatment with pemafibrate XR.",
  "abstract_shown": true,
  "affiliations": [],
  "article_type": null,
  "arxiv": null,
  "author_total": 6,
  "authors": [
    {
      "name": "Saori Inoue"
    },
    {
      "name": "Takashi Kamiya"
    },
    {
      "name": "Syusaku Kanemori"
    },
    {
      "name": "Reiichiro Fujita"
    },
    {
      "name": "Aya Morita"
    },
    {
      "name": "Hiroko Yasuda"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fedd95hn0b0re.bib",
  "cited_by": 0,
  "doi": "10.2169/internalmedicine.8208-26",
  "fulltext_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8208-26/_article",
  "id": "fedd95hn0b0re",
  "issns": [
    "1349-7235",
    "0918-2918"
  ],
  "landing_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8208-26/_article",
  "language": null,
  "licence": "CC-BY-NC-ND",
  "licence_label": "CC BY-NC-ND",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by-nc-nd/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "jstage-journal",
      "medicine/general"
    ],
    [
      "openalex",
      "2705|Lipid metabolism and disorders"
    ]
  ],
  "openalex": "W7214658455",
  "pdf_url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8208-26/_pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-09-29",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fedd95hn0b0re.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:17:31Z",
      "native_id": "10.2169/internalmedicine.8208-26",
      "source": "jstage",
      "url": "https://www.jstage.jst.go.jp/article/internalmedicine/advpub/0/advpub_8208-26/_article"
    }
  ],
  "subjects": [
    {
      "field": "medicine",
      "origin": "openalex:2705|Lipid metabolism and disorders",
      "subfield": "cardiovascular"
    }
  ],
  "title": "Real-World Effects of Pemafibrate Extended-Release in Patients with Hypertriglyceridemia: A 12-Month Retrospective Study",
  "title_text": "Real-World Effects of Pemafibrate Extended-Release in Patients with Hypertriglyceridemia: A 12-Month Retrospective Study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T12:17:31Z",
  "url": "https://research.draconitic.com/paper/fedd95hn0b0re",
  "venue": "Internal Medicine",
  "versions": []
}