{
  "abstract": "Background: Multisystem inflammatory syndrome in children (MIS-C) is a severe post-infectious complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The condition has limited evidence and requires further exploration in countries such as India. Objectives: To estimate the proportion of suspected cases classified as MIS-C and describe clinical features, severity, treatment and outcomes within the Indian Council of Medical Research (ICMR) National Clinical Registry for COVID-19. Methods: Twelve tertiary hospitals in 11 states and union territories contributed to a registry extension, with retrospective review (April 2020-December 2022) and prospective surveillance (January 2023-June 2024). Cases were classified using the World Health Organization (WHO) definition, and analyses used the data available for each variable. Results: Of 217 suspected cases, 41 (18.9%; 95% confidence interval 14.2-24.6%) were classified as MIS-C and 176 as not confirmed. Among confirmed cases, 43.9% were aged 0-4 years, 53.7% were aged 5-14 years, and 70.7% were male. Fever was universal; shock and respiratory features were more frequent than in not confirmed cases. Of 35 confirmed children with data, 21 (60.0%) required intensive care, and one of 41 died. Corticosteroids and intravenous immunoglobulin were administered to 65.9% and 61.0% of patients, respectively. Conclusion: Extending an existing registry to paediatric departments provided a multicentric estimate among hospitalised suspected cases and a practical model for paediatric surveillance in resource-limited settings.",
  "abstract_shown": true,
  "affiliations": [
    "SD Gupta School of Public Health, IIHMR University, Jaipur, Rajasthan, India; Corresponding author. SD Gupta School of Public Health, IIHMR University, 1 Prabhu Dayal Marg, Sanganer, Jaipur, 302029, Rajasthan, India.",
    "SD Gupta School of Public Health, IIHMR University, Jaipur, Rajasthan, India",
    "Indian Council of Medical Research Headquarters, New Delhi, India",
    "National Institute of Child Health Research, New Delhi, India",
    "Kakatiya Medical College, Warangal, Telangana, India",
    "Osmania Medical College, Hyderabad, Telangana, India",
    "Indian Council of Medical Research-National Institute of Health Research, Jodhpur, Rajasthan, India",
    "Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, New Delhi, Delhi, 110029, India",
    "Dr D Y Patil Medical College & Research Centre, Pimpri, Pune, Maharashtra, 411018, India; Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, New Delhi, Delhi, 110029, India",
    "Dr D Y Patil Medical College & Research Centre, Pimpri, Pune, Maharashtra, 411018, India",
    "Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh, India",
    "Postgraduate Institute of Medical Education and Research, Chandigarh, India",
    "St. John's Medical College, Bengaluru, Karnataka, India",
    "North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India"
  ],
  "article_type": null,
  "arxiv": null,
  "author_total": 30,
  "authors": [
    {
      "affs": [
        0
      ],
      "name": "Anoop Velayudhan"
    },
    {
      "affs": [
        1
      ],
      "name": "P. Majumdar"
    },
    {
      "affs": [
        2
      ],
      "name": "G. Kumar"
    },
    {
      "affs": [
        3
      ],
      "name": "A. Turuk"
    },
    {
      "affs": [
        2
      ],
      "name": "Anshuman Thakur"
    },
    {
      "affs": [
        4
      ],
      "name": "Sharma SK"
    },
    {
      "affs": [
        3
      ],
      "name": "P. Shukla"
    },
    {
      "affs": [
        4
      ],
      "name": "Chander BT"
    },
    {
      "affs": [
        4
      ],
      "name": "V. Rajesh"
    },
    {
      "affs": [
        5
      ],
      "name": "M. Rajarao"
    },
    {
      "affs": [
        6
      ],
      "name": "P. Bhardwaj"
    },
    {
      "affs": [
        7
      ],
      "name": "A. Kumar"
    },
    {
      "affs": [
        7
      ],
      "name": "I. Saini"
    },
    {
      "affs": [
        8
      ],
      "name": "A. Singh"
    },
    {
      "affs": [
        9
      ],
      "name": "S. Shivnitwar"
    },
    {
      "affs": [
        9
      ],
      "name": "S. Tripathy"
    },
    {
      "affs": [
        9
      ],
      "name": "S. Kanitkar"
    },
    {
      "affs": [
        9
      ],
      "name": "M. Barthwal"
    },
    {
      "affs": [
        9
      ],
      "name": "A.L. Kakrani"
    },
    {
      "affs": [
        10
      ],
      "name": "S. Mane"
    },
    {
      "affs": [
        10
      ],
      "name": "M. Shameem"
    },
    {
      "affs": [
        10
      ],
      "name": "N. Fatima"
    },
    {
      "affs": [
        11
      ],
      "name": "A. Bhalla"
    },
    {
      "affs": [
        11
      ],
      "name": "J. Murlidharan"
    },
    {
      "affs": [
        11
      ],
      "name": "S. Paul"
    },
    {
      "affs": [
        12
      ],
      "name": "R. Choudhury"
    },
    {
      "affs": [
        12
      ],
      "name": "M. Rao"
    },
    {
      "affs": [
        13
      ],
      "name": "S. Pala"
    },
    {
      "affs": [
        13
      ],
      "name": "H. Barman"
    },
    {
      "affs": [
        3
      ],
      "name": "A. Mukherjee"
    }
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  "bibtex": "https://research.draconitic.com/paper/femt9d4276mwc.bib",
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  "doi": "10.1016/j.cegh.2026.102512",
  "fulltext_url": "http://www.sciencedirect.com/science/article/pii/S2213398426002277",
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  "issns": [
    "2213-3984",
    "2452-0918"
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  "landing_url": "https://doi.org/10.1016/j.cegh.2026.102512",
  "language": "en",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "journal",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
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      "2746|Kawasaki Disease and Coronary Complications"
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  "openalex": "W7222232042",
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  "published": "2026-10-30",
  "publisher": "Elsevier",
  "ris": "https://research.draconitic.com/paper/femt9d4276mwc.ris",
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    {
      "first_seen": "2026-10-30T13:44:53Z",
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      "subfield": "surgery"
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  "title": "Multisystem inflammatory syndrome in children (MIS-C) burden in India: A multicentre implementation research study",
  "title_text": "Multisystem inflammatory syndrome in children (MIS-C) burden in India: A multicentre implementation research study",
  "type": "peer-reviewed",
  "updated_at": "2026-10-30T13:44:53Z",
  "url": "https://research.draconitic.com/paper/femt9d4276mwc",
  "venue": "Clinical Epidemiology and Global Health",
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}