{
  "abstract": "Astrocytic processes closely associate with excitatory synapses and express AMPARs, positioning them to sense the same glutamate signals as neurons. Whether a mismatch between neuronal and astrocytic glutamate sensing affects synaptic physiology is unknown. Using AstroHTP, an extension of Drug Acutely Restricted by Tethering (DART) for cell-type-specific pharmacology, we found that acute astrocytic AMPAR inhibition spared neuronal AMPARs and basal transmission yet converted ongoing glutamatergic activity into a remarkably potent form of long-term depression (LTD) in mouse striatal projection neurons (SPNs). Unlike canonical presynaptic LTD, this form of LTD manifests postsynaptically, requires non-ionotropic NMDA receptor signaling, and arises when glutamate transmission occurs without a matching astrocytic signal. Astrocytic glutamate sensing through AMPARs, therefore, acts as a parity signal that verifies transmission and stabilizes active synapses.",
  "abstract_shown": true,
  "affiliations": [
    "Department of Cell Biology, Duke University School of Medicine, Durham, NC, USA; Howard Hughes Medical Institute, Chevy Chase, MD, USA; Aligning Science Across"
  ],
  "article_type": "New results",
  "arxiv": null,
  "author_total": 15,
  "authors": [
    {
      "name": "N. Elazar"
    },
    {
      "name": "J. R. Ravenel"
    },
    {
      "name": "J. Kim"
    },
    {
      "name": "T. Vaidyanathan"
    },
    {
      "name": "O. Wirfel-Farenchak"
    },
    {
      "name": "K. Uryu"
    },
    {
      "name": "S. S. X. Lim"
    },
    {
      "name": "J. R. Roach"
    },
    {
      "name": "W. Zhang"
    },
    {
      "name": "X. Cao"
    },
    {
      "name": "M. E. van Praag"
    },
    {
      "name": "H. Yan"
    },
    {
      "name": "G. Yu"
    },
    {
      "name": "M. R. Tadross"
    },
    {
      "affs": [
        0
      ],
      "name": "C. Eroglu"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/fenm98ant1p0t.bib",
  "cited_by": 0,
  "doi": "10.64898/2026.10.08.757679",
  "fulltext_url": "https://www.biorxiv.org/content/10.64898/2026.10.08.757679v1.full",
  "id": "fenm98ant1p0t",
  "issns": [],
  "landing_url": "https://www.biorxiv.org/content/10.64898/2026.10.08.757679v1",
  "language": null,
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "biorxiv",
      "neuroscience"
    ],
    [
      "openalex",
      "2804|Neuroscience and Neuropharmacology Research"
    ]
  ],
  "openalex": "W7221439827",
  "pdf_url": "https://www.biorxiv.org/content/10.64898/2026.10.08.757679v1.full.pdf",
  "pmcid": null,
  "pmid": null,
  "published": "2026-10-08",
  "publisher": null,
  "ris": "https://research.draconitic.com/paper/fenm98ant1p0t.ris",
  "sources": [
    {
      "first_seen": "2026-10-30T12:27:04Z",
      "native_id": "10.64898/2026.10.08.757679",
      "source": "biorxiv",
      "url": "https://www.biorxiv.org/content/10.64898/2026.10.08.757679v1"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "biorxiv:neuroscience",
      "subfield": "neuroscience"
    }
  ],
  "title": "An astrocytic AMPAR-dependent parity signal preserves synaptic strength",
  "title_text": "An astrocytic AMPAR-dependent parity signal preserves synaptic strength",
  "type": "preprint",
  "updated_at": "2026-10-30T12:27:04Z",
  "url": "https://research.draconitic.com/paper/fenm98ant1p0t",
  "venue": "bioRxiv",
  "versions": []
}