{
  "abstract": "Maturity-onset diabetes of the young (MODY) is frequently misdiagnosed, but an accurate diagnosis can inform tailored diabetes management. A quality improvement project was launched in 2022 at a pediatric tertiary care center to (1) increase MODY testing among individuals with islet autoantibody-negative (IAb-) new-onset diabetes mellitus (NODM) and (2) increase provider awareness of MODY. Interventions targeted the primary drivers, including provider recognition of MODY and barriers to testing. Each month, an electronic medical record report identified patients with IAb- NODM diagnosed within the prior 3 months. A standardized previsit email was sent to the treating provider that (1) flagged IAb- status, (2) outlined MODY testing criteria, and (3) provided instructions for ordering genetic testing when indicated. The primary outcome, MODY tests ordered among eligible patients, was analyzed longitudinally using a control chart. Provider awareness of MODY and perceptions of the intervention were assessed in May 2023 and March 2024. The proportion of patients with IAb- NODM tested for MODY at a clinic visit within 365 days of diagnosis increased from 2.87% at baseline (January/February 2021-May/June 2022) to 9.94% after the quality improvement project launch in July/August 2022. Among completed tests through October 2025, 9 of 28 (32.1%) identified a pathogenic or likely pathogenic MODY variant. Providers' familiarity with MODY testing criteria also improved, with those reporting being \"extremely familiar\" increasing from 0% (0/20) to 17% (3/18). The project, including the targeted previsit provider email, was associated with increased MODY testing and improved provider awareness in a pediatric diabetes clinic.",
  "abstract_shown": true,
  "affiliations": [
    "From the Division of Endocrinology, Boston Children's Hospital, Boston, Mass.",
    "Department of Pediatrics, Harvard Medical School, Boston, Mass.",
    "The Broad Institute of MIT and Harvard, Cambridge, Mass.",
    "Division of Endocrinology & Diabetes, Children's Hospital of Philadelphia, Philadelphia, Pa.",
    "University of Pennsylvania Perelman School of Medicine, Philadelphia, Pa."
  ],
  "article_type": "research article",
  "arxiv": null,
  "author_total": 8,
  "authors": [
    {
      "affs": [
        0,
        1,
        2
      ],
      "name": "Raymond J Kreienkamp"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jessica L Ruiz"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Sarah Schlegel"
    },
    {
      "affs": [
        0
      ],
      "name": "Olivia Sterns"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Jia Zhu"
    },
    {
      "affs": [
        3,
        4
      ],
      "name": "Tara Maxwell"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Christine E Cherella"
    },
    {
      "affs": [
        0,
        1
      ],
      "name": "Erinn T Rhodes"
    }
  ],
  "bibtex": "https://research.draconitic.com/paper/ff3x1prb7c64s.bib",
  "cited_by": 0,
  "doi": "10.1097/pq9.0000000000000937",
  "fulltext_url": "https://europepmc.org/articles/PMC13716420",
  "id": "ff3x1prb7c64s",
  "issns": [
    "2472-0054"
  ],
  "landing_url": "https://europepmc.org/article/MED/42953899",
  "language": "eng",
  "licence": "CC-BY",
  "licence_label": "CC BY",
  "licence_source": "article",
  "licence_url": "https://creativecommons.org/licenses/by/4.0/",
  "metadata_licence": null,
  "native_subjects": [
    [
      "heading",
      "Individual QI projects from single institutions"
    ],
    [
      "openalex",
      "1311|Diabetes and associated disorders"
    ]
  ],
  "openalex": "W7224293867",
  "pdf_url": "https://europepmc.org/articles/PMC13716420?pdf=render",
  "pmcid": "PMC13716420",
  "pmid": "42953899",
  "published": "2026-10-28",
  "publisher": "Wolters Kluwer Health",
  "ris": "https://research.draconitic.com/paper/ff3x1prb7c64s.ris",
  "sources": [
    {
      "first_seen": "2026-10-31T00:20:40Z",
      "native_id": "MED:42953899",
      "source": "europepmc",
      "url": "https://europepmc.org/article/MED/42953899"
    },
    {
      "first_seen": "2026-11-01T12:23:24Z",
      "native_id": "PMC13716420",
      "source": "pmc",
      "url": "https://doi.org/10.1097/pq9.0000000000000937"
    }
  ],
  "subjects": [
    {
      "field": "biology",
      "origin": "openalex:1311|Diabetes and associated disorders",
      "subfield": "genetics-genomics"
    }
  ],
  "title": "Increasing Awareness and Identification of Maturity-Onset Diabetes of the Young in a Pediatric Diabetes Program.",
  "title_text": "Increasing Awareness and Identification of Maturity-Onset Diabetes of the Young in a Pediatric Diabetes Program.",
  "type": "peer-reviewed",
  "updated_at": "2026-11-01T12:23:24Z",
  "url": "https://research.draconitic.com/paper/ff3x1prb7c64s",
  "venue": "Pediatric quality & safety",
  "versions": []
}